Chloridazon-catechol dioxygenase

From Wikipedia, the free encyclopedia

In enzymology, a chloridazon-catechol dioxygenase (EC 1.13.11.36) is an enzyme that catalyzes the chemical reaction

5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone + O₂ $\rightleftharpoons$ 5-amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone

Thus, the two substrates of this enzyme are 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone and O₂, whereas its product is 5-amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing). It employs one cofactor, iron.

[edit] References

IUBMB entry for 1.13.11.36
BRENDA references for 1.13.11.36 (Recommended.)
PubMed references for 1.13.11.36
PubMed Central references for 1.13.11.36
Google Scholar references for 1.13.11.36
Muller R, Haug S, Eberspacher J, Lingens F (1977). "[Catechol 2,3-dioxygenase from pyrazon-degrading bacteria (author's transl)]". Hoppe. Seylers. Z. Physiol. Chem. 358: 797–805. PMID 19349.
Muller R, Schmitt S, Lingens F (1982). "A novel non-heme iron-containing dioxygenase. Chloridazon-catechol dioxygenase from Phenylobacterium immobilis DSM 1986". Eur. J. Biochem. 125: 579–84. doi:10.1111/j.1432-1033.1982.tb06722.x. PMID 6811270.