Chlordecone reductase

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In enzymology, a chlordecone reductase (EC 1.1.1.225) is an enzyme that catalyzes the chemical reaction

chlordecone alcohol + NADP⁺ chlordecone + NADPH + H⁺

Thus, the two substrates of this enzyme are chlordecone alcohol and NADP⁺, whereas its 3 products are chlordecone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is chlordecone-alcohol:NADP+ 2-oxidoreductase. This enzyme is also called CDR.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2FVL.

[edit] References

• IUBMB entry for 1.1.1.225
• BRENDA references for 1.1.1.225 (Recommended.)
• PubMed references for 1.1.1.225
• PubMed Central references for 1.1.1.225
• Google Scholar references for 1.1.1.225
• Molowa DT, Shayne AG, Guzelian PS (1986). "Purification and characterization of chlordecone reductase from human liver". J. Biol. Chem. 261: 12624–7. PMID 2427522. 

[edit] External links

The CAS registry number for this enzyme class is 102484-73-1.

• IUBMB entry for 1.1.1.225

• KEGG entry for 1.1.1.225

• BRENDA entry for 1.1.1.225

• NiceZyme view of 1.1.1.225

• EC2PDB: PDB structures for 1.1.1.225

• PRIAM entry for 1.1.1.225

• PUMA2 entry for 1.1.1.225

• IntEnz: Integrated Enzyme entry for 1.1.1.225

• MetaCyc entry for 1.1.1.225

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047743: chlordecone reductase

• AMIGO entry for GO code 0047743: chlordecone reductase