ChGn

From Wikipedia, the free encyclopedia

Chondroitin beta1,4 N-acetylgalactosaminyltransferase

Identifiers

ChGn; FLJ11264; beta4GalNAcT

External IDs

Gene ontology
Molecular Function:	• protein binding • peptidoglycan glycosyltransferase activity • glucuronosyltransferase activity • transferase activity • metal ion binding • glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity • glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
Cellular Component:	• intracellular • soluble fraction • membrane • integral to membrane • integral to Golgi membrane
Biological Process:	• nervous system development • cell recognition • cell proliferation • anatomical structure morphogenesis • heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process • UDP-N-acetylgalactosamine metabolic process • extracellular matrix organization and biogenesis • chondroitin sulfate biosynthetic process • heparin biosynthetic process • UDP-glucuronate metabolic process • dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process • chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018371 (mRNA)
NP_060841 (protein)

NM_172753 (mRNA)
NP_766341 (protein)

Location

Chr 8: 19.31 - 19.58 Mb

Chr 8: 71.29 - 71.66 Mb

Pubmed search

[1]

[2]

Chondroitin beta1,4 N-acetylgalactosaminyltransferase, also known as ChGn, is a human gene.^[1]

[edit] References

^ Entrez Gene: ChGn chondroitin beta1,4 N-acetylgalactosaminyltransferase.

[edit] Further reading

Sakai K, Kimata K, Sato T, et al. (2007). "Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage.". J. Biol. Chem. 282 (6): 4152-61. doi:10.1074/jbc.M606870200. PMID 17145758.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sato T, Gotoh M, Kiyohara K, et al. (2003). "Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate.". J. Biol. Chem. 278 (5): 3063-71. doi:10.1074/jbc.M208886200. PMID 12446672.
Gotoh M, Sato T, Akashima T, et al. (2002). "Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis.". J. Biol. Chem. 277 (41): 38189-96. doi:10.1074/jbc.M203619200. PMID 12163485.
Uyama T, Kitagawa H, Tamura Ji J, Sugahara K (2002). "Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate.". J. Biol. Chem. 277 (11): 8841-6. doi:10.1074/jbc.M111434200. PMID 11788602.
Kitagawa H, Uyama T, Sugahara K (2001). "Molecular cloning and expression of a human chondroitin synthase.". J. Biol. Chem. 276 (42): 38721-6. doi:10.1074/jbc.M106871200. PMID 11514575.