CHFR

From Wikipedia, the free encyclopedia

Checkpoint with forkhead and ring finger domains

PDB rendering based on 1lgp.

Available structures: 1lgp, 1lgq

Identifiers

Symbol(s)

CHFR; FLJ10796; FLJ33629; RNF116; RNF196

External IDs

OMIM: 605209 MGI: 2444898 HomoloGene: 10078

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • protein binding • zinc ion binding • ligase activity • metal ion binding
Cellular Component:	• cellular_component • nucleus
Biological Process:	• protein polyubiquitination • mitotic cell cycle • ubiquitin-dependent protein catabolic process • ubiquitin cycle • mitosis • mitotic cell cycle checkpoint • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018223 (mRNA)
NP_060693 (protein)

NM_172717 (mRNA)
NP_766305 (protein)

Location

Chr 12: 131.93 - 131.97 Mb

Chr 5: 110.38 - 110.41 Mb

Pubmed search

[1]

[2]

Checkpoint with forkhead and ring finger domains, also known as CHFR, is a human gene.^[1]

[edit] References

^ Entrez Gene: CHFR checkpoint with forkhead and ring finger domains.

[edit] Further reading

Scolnick DM, Halazonetis TD (2000). "Chfr defines a mitotic stress checkpoint that delays entry into metaphase.". Nature 406 (6794): 430-5. doi:10.1038/35019108. PMID 10935642.
Kang D, Chen J, Wong J, Fang G (2002). "The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition.". J. Cell Biol. 156 (2): 249-59. doi:10.1083/jcb.200108016. PMID 11807090.
Chaturvedi P, Sudakin V, Bobiak ML, et al. (2002). "Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity.". Cancer Res. 62 (6): 1797-801. PMID 11912157.
Mizuno K, Osada H, Konishi H, et al. (2002). "Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers.". Oncogene 21 (15): 2328-33. doi:10.1038/sj.onc.1205402. PMID 11948416.
Stavridi ES, Huyen Y, Loreto IR, et al. (2002). "Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate.". Structure 10 (7): 891-9. PMID 12121644.
Shibata Y, Haruki N, Kuwabara Y, et al. (2002). "Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer.". Carcinogenesis 23 (10): 1695-9. PMID 12376479.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Corn PG, Summers MK, Fogt F, et al. (2003). "Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.". Carcinogenesis 24 (1): 47-51. PMID 12538348.
Toyota M, Sasaki Y, Satoh A, et al. (2003). "Epigenetic inactivation of CHFR in human tumors.". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7818-23. doi:10.1073/pnas.1337066100. PMID 12810945.
Bothos J, Summers MK, Venere M, et al. (2003). "The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains.". Oncogene 22 (46): 7101-7. doi:10.1038/sj.onc.1206831. PMID 14562038.
Mariatos G, Bothos J, Zacharatos P, et al. (2004). "Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer.". Cancer Res. 63 (21): 7185-9. PMID 14612512.
Shtivelman E (2004). "Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFR.". Mol. Cancer Res. 1 (13): 959-69. PMID 14638868.
Bertholon J, Wang Q, Falette N, et al. (2004). "Chfr inactivation is not associated to chromosomal instability in colon cancers.". Oncogene 22 (55): 8956-60. doi:10.1038/sj.onc.1207078. PMID 14654793.
Erson AE, Petty EM (2004). "CHFR-associated early G2/M checkpoint defects in breast cancer cells.". Mol. Carcinog. 39 (1): 26-33. doi:10.1002/mc.10161. PMID 14694445.
Satoh A, Toyota M, Itoh F, et al. (2004). "Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer.". Cancer Res. 63 (24): 8606-13. PMID 14695171.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Kang HC, Kim IJ, Park JH, et al. (2005). "Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers.". Oncol. Rep. 12 (1): 129-33. PMID 15201973.
Matsusaka T, Pines J (2004). "Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells.". J. Cell Biol. 166 (4): 507-16. doi:10.1083/jcb.200401139. PMID 15302856.
Daniels MJ, Marson A, Venkitaraman AR (2004). "PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein.". Nat. Struct. Mol. Biol. 11 (11): 1114-21. doi:10.1038/nsmb837. PMID 15467728.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.