CHD8

From Wikipedia, the free encyclopedia

Chromodomain helicase DNA binding protein 8

PDB rendering based on 2dl6.

Available structures: 2dl6

Identifiers

Symbol(s)

CHD8; DKFZp686N17164; HELSNF1; KIAA1564

External IDs

OMIM: 610528 MGI: 1915022 HomoloGene: 72405

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • chromatin binding • helicase activity • protein binding • ATP binding • hydrolase activity • transcription regulator activity
Cellular Component:	• chromatin • nucleus
Biological Process:	• chromatin assembly or disassembly • transcription • regulation of transcription, DNA-dependent • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_020920 (mRNA)
NP_065971 (protein)

XM_619244 (mRNA)
XP_619244 (protein)

Location

Chr 14: 20.92 - 20.98 Mb

Chr 14: 51.12 - 51.14 Mb

Pubmed search

[1]

[2]

Chromodomain helicase DNA binding protein 8, also known as CHD8, is a human gene.^[1]

[edit] References

^ Entrez Gene: CHD8 chromodomain helicase DNA binding protein 8.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Epplen C, Epplen JT (1994). "Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes.". Hum. Genet. 93 (1): 35-41. PMID 7505766.
Sakamoto I, Kishida S, Fukui A, et al. (2000). "A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation.". J. Biol. Chem. 275 (42): 32871-8. doi:10.1074/jbc.M004089200. PMID 10921920.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273-81. PMID 10997877.
Kobayashi M, Hanai R (2001). "M phase-specific association of human topoisomerase IIIbeta with chromosomes.". Biochem. Biophys. Res. Commun. 287 (1): 282-7. doi:10.1006/bbrc.2001.5580. PMID 11549288.
Kobayashi M, Kishida S, Fukui A, et al. (2002). "Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway.". J. Biol. Chem. 277 (8): 5816-22. doi:10.1074/jbc.M108433200. PMID 11744694.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Nishiyama M, Nakayama K, Tsunematsu R, et al. (2004). "Early embryonic death in mice lacking the beta-catenin-binding protein Duplin.". Mol. Cell. Biol. 24 (19): 8386-94. doi:10.1128/MCB.24.19.8386-8394.2004. PMID 15367660.
Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo.". Mol. Cell. Biol. 24 (20): 9176-85. doi:10.1128/MCB.24.20.9176-9185.2004. PMID 15456888.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ishihara K, Oshimura M, Nakao M (2006). "CTCF-dependent chromatin insulator is linked to epigenetic remodeling.". Mol. Cell 23 (5): 733-42. doi:10.1016/j.molcel.2006.08.008. PMID 16949368.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Yuan CC, Zhao X, Florens L, et al. (2007). "CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription.". Mol. Cell. Biol. 27 (24): 8729-38. doi:10.1128/MCB.00846-07. PMID 17938208.