CHD2

From Wikipedia, the free encyclopedia

Chromodomain helicase DNA binding protein 2

Identifiers

CHD2; DKFZp781D1727

External IDs

OMIM: 602119 MGI: 2448567 HomoloGene: 37462

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • chromatin binding • ATP-dependent DNA helicase activity • helicase activity • ATP binding • hydrolase activity
Cellular Component:	• chromatin • nucleus
Biological Process:	• chromatin assembly or disassembly • regulation of transcription from RNA polymerase II promoter • chromosome organization and biogenesis (sensu Eukaryota)

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001042572 (mRNA)
NP_001036037 (protein)

XM_897304 (mRNA)
XP_902397 (protein)

Location

Chr 15: 91.24 - 91.37 Mb

Chr 7: 73.33 - 73.41 Mb

Pubmed search

[1]

[2]

Chromodomain helicase DNA binding protein 2, also known as CHD2, is a human gene.^[1]

The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: CHD2 chromodomain helicase DNA binding protein 2.

[edit] Further reading

Feys T, Poppe B, De Preter K, et al. (2007). "A detailed inventory of DNA copy number alterations in four commonly used Hodgkin's lymphoma cell lines.". Haematologica 92 (7): 913-20. PMID 17606441.
Zody MC, Garber M, Sharpe T, et al. (2006). "Analysis of the DNA sequence and duplication history of human chromosome 15.". Nature 440 (7084): 671-5. doi:10.1038/nature04601. PMID 16572171.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Hiller M, Huse K, Platzer M, Backofen R (2005). "Non-EST based prediction of exon skipping and intron retention events using Pfam information.". Nucleic Acids Res. 33 (17): 5611-21. doi:10.1093/nar/gki870. PMID 16204458.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Johnson JM, Castle J, Garrett-Engele P, et al. (2004). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.". Science 302 (5653): 2141-4. doi:10.1126/science.1090100. PMID 14684825.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Woodage T, Basrai MA, Baxevanis AD, et al. (1997). "Characterization of the CHD family of proteins.". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11472-7. PMID 9326634.