CGS21680

From Wikipedia, the free encyclopedia

CGS21680
IUPAC name	3-[4-[2-[ [6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid
Other names	CGS 21680
Identifiers
CAS number	[120225-54-9]
PubChem	3086599
SMILES	CCNC(=O)[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C2N=C(N=C3N)NCCC4=CC=C(C=C4)CCC(=O)O)O)O
Properties
Molecular formula	C23H29N7O6
Molar mass	499.52
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

CGS21680 is a specific adenosine A_2A subtype receptor agonist. It is usually presented as an organic hydrochloride salt with a molecular weight of 536.0 g/M. It is soluble up to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin.

The chemical is currently used by researchers interested in studying neuronal transmission with a high-affinity, subtype specific analogue for adenosine. This includes research in respiration where it is believed that A_2A receptors are involved in rhythm generation in the pre-Bötzinger complex. The drug is not currently approved for use in a therapeutic capacity.

It is currently manufactured by Tocris with the exclusive permission of Novartis Pharma AG, U.S. Patent 4,968,697.

[edit] See also

• Adenosine receptor

[edit] References

• Mayer CA, Haxhiu MA, Martin RJ, Wilson CG (2006). "Adenosine A_2A receptors mediate GABAergic inhibition of respiration in immature rats". J Appl Physiol 100 (1): 91–97. doi:10.1152/japplphysiol.00459.2005. PMID 16141383. 
• Xie S, Shafer G, Wilson CG, Martin HB (2006). "In vitro adenosine detection with a diamond-based sensor". Dia Rel Mater 15 (2-3): 225–228. doi:10.1016/j.diamond.2005.08.018.