Cgk733

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CGK733
CGK733

CGK733 is a synthetic substance whose molecular structure is shown in the diagram.[1]

It is a complex thiourea derivative which has remarkable properties in reversing cell senescence (aging). Experiments have shown that it can extend the lifetime of cultured cells by approximately 20 divisions, or roughly 25%, specifically in mammalian cells. Current research is investigating its potential uses in wound healing, antiaging cosmetics and tissue engineering.

Tae Kook Kim[2] and several associates at the Korea Advanced Institute of Science & Technology discovered its properties as a result of screening twenty thousand synthetic molecules for their effects on aging cells.

It is an inhibitor of ATM/ATR kinases, which are involved in DNA damage repair.

The entire work behind the discovery of this compound has been called into question and found to be falsified. [3][4]

[edit] References

  1. ^ Sarah Everts (2006). Aging Cells Get New Lease On Life - Small molecule is found to extend lifetime of mammalian cells. Chemical & Engineering News. Retrieved on 2007-03-09.
  2. ^ Professor Tae Kook Kim. Molecular Genomics & Medicinal Systems Biology. Retrieved on 2007-03-09.
  3. ^ Dennis Normile and Jennifer Couzin (2008). South Korean Researcher Suspended Over Charges of Scientific Misconduct. Science. Retrieved on 2008-03-17.
  4. ^ Kenneth J. Moore (2008). Data Duping. Chemical & Engineering News. Retrieved on 2008-04-01.


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