CFHR1

From Wikipedia, the free encyclopedia


Complement factor H-related 1
PDB rendering based on 2bzm.
Available structures: 2bzm, 2g7i
Identifiers
Symbol(s) CFHR1; CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; H36-1; H36-2; HFL1; HFL2; MGC104329
External IDs OMIM: 134371 MGI: 2138169 HomoloGene: 55632
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3078 50702
Ensembl ENSG00000080910 ENSMUSG00000057037
Uniprot Q03591 n/a
Refseq NM_002113 (mRNA)
NP_002104 (protein)		 NM_015780 (mRNA)
NP_056595 (protein)
Location Chr 1: 195.06 - 195.07 Mb Chr 1: 141.36 - 141.6 Mb
Pubmed search [1] [2]

Complement factor H-related 1, also known as CFHR1, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: CFHR1 complement factor H-related 1.

[edit] Further reading

  • Zipfel PF, Skerka C (1994). "Complement factor H and related proteins: an expanding family of complement-regulatory proteins?". Immunol. Today 15 (3): 121–6. PMID 8172644. 
  • Zipfel PF, Jokiranta TS, Hellwage J, et al. (1999). "The factor H protein family.". Immunopharmacology 42 (1-3): 53–60. PMID 10408366. 
  • Skerka C, Horstmann RD, Zipfel PF (1991). "Molecular cloning of a human serum protein structurally related to complement factor H.". J. Biol. Chem. 266 (18): 12015–20. PMID 1711047. 
  • Timmann C, Leippe M, Horstmann RD (1991). "Two major serum components antigenically related to complement factor H are different glycosylation forms of a single protein with no factor H-like complement regulatory functions.". J. Immunol. 146 (4): 1265–70. PMID 1825108. 
  • Estaller C, Koistinen V, Schwaeble W, et al. (1991). "Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule.". J. Immunol. 146 (9): 3190–6. PMID 1826708. 
  • Park CT, Wright SD (1996). "Plasma lipopolysaccharide-binding protein is found associated with a particle containing apolipoprotein A-I, phospholipid, and factor H-related proteins.". J. Biol. Chem. 271 (30): 18054–60. PMID 8663389. 
  • Díaz-Guillén MA, Rodríguez de Córdoba S, Heine-Suñer D (1999). "A radiation hybrid map of complement factor H and factor H-related genes.". Immunogenetics 49 (6): 549–52. PMID 10380701. 
  • Male DA, Ormsby RJ, Ranganathan S, et al. (2000). "Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes.". Mol. Immunol. 37 (1-2): 41–52. PMID 10781834. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Pérez-Caballero D, García-Laorden I, Cortés G, et al. (2005). "Interaction between complement regulators and Streptococcus pyogenes: binding of C4b-binding protein and factor H/factor H-like protein 1 to M18 strains involves two different cell surface molecules.". J. Immunol. 173 (11): 6899–904. PMID 15557185. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • McDowell JV, Lankford J, Stamm L, et al. (2005). "Demonstration of factor H-like protein 1 binding to Treponema denticola, a pathogen associated with periodontal disease in humans.". Infect. Immun. 73 (11): 7126–32. doi:10.1128/IAI.73.11.7126-7132.2005. PMID 16239506. 
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Zipfel PF, Edey M, Heinen S, et al. (2007). "Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome.". PLoS Genet. 3 (3): e41. doi:10.1371/journal.pgen.0030041. PMID 17367211. 
  • Haupt K, Kraiczy P, Wallich R, et al. (2007). "Binding of human factor H-related protein 1 to serum-resistant Borrelia burgdorferi is mediated by borrelial complement regulator-acquiring surface proteins.". J. Infect. Dis. 196 (1): 124–33. doi:10.1086/518509. PMID 17538892. 
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