CETN1

From Wikipedia, the free encyclopedia

Centrin, EF-hand protein, 1

PDB rendering based on 1m39.

Available structures: 1m39, 2a4j

Identifiers

Symbol(s)

CETN1; CEN1; CETN

External IDs

OMIM: 603187 MGI: 1347086 HomoloGene: 55798

Gene ontology
Molecular Function:	• calcium ion binding
Cellular Component:	• centrosome • spindle pole body • cytoskeleton
Biological Process:	• cell cycle • mitosis • mitotic centrosome separation • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004066 (mRNA)
NP_004057 (protein)

NM_007593 (mRNA)
NP_031619 (protein)

Location

Chr 18: 0.57 - 0.57 Mb

Chr 18: 9.62 - 9.62 Mb

Pubmed search

[1]

[2]

Centrin, EF-hand protein, 1, also known as CETN1, is a human gene.^[1]

The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.^[1]

[edit] References

^ ^a ^b Entrez Gene: CETN1 centrin, EF-hand protein, 1.

[edit] Further reading

Tsang WY, Spektor A, Luciano DJ, et al. (2006). "CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.". Mol. Biol. Cell 17 (8): 3423–34. doi:10.1091/mbc.E06-04-0371. PMID 16760425.
Zhao ZS, Lim JP, Ng YW, et al. (2006). "The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.". Mol. Cell 20 (2): 237–49. doi:10.1016/j.molcel.2005.08.035. PMID 16246726.
Poole E, Strappe P, Mok HP, et al. (2005). "HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET.". Traffic 6 (9): 741–55. doi:10.1111/j.1600-0854.2005.00312.x. PMID 16101678.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lutz W, Lingle WL, McCormick D, et al. (2001). "Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication.". J. Biol. Chem. 276 (23): 20774–80. doi:10.1074/jbc.M101324200. PMID 11279195.
Laoukili J, Perret E, Middendorp S, et al. (2000). "Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro.". J. Cell. Sci. 113 ( Pt 8): 1355–64. PMID 10725219.
Errabolu R, Sanders MA, Salisbury JL (1994). "Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles.". J. Cell. Sci. 107 ( Pt 1): 9–16. PMID 8175926.