CES2

From Wikipedia, the free encyclopedia

Carboxylesterase 2 (intestine, liver)

Identifiers

CES2; CE-2; CES2A1; PCE-2; iCE

External IDs

OMIM: 605278 MGI: 3648740 HomoloGene: 55787

Gene ontology
Molecular Function:	• carboxylesterase activity • hydrolase activity
Cellular Component:	• endoplasmic reticulum
Biological Process:	• catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003869 (mRNA)
NP_003860 (protein)

XM_488149 (mRNA)
XP_488149 (protein)

Location

Chr 16: 65.53 - 65.54 Mb

n/a

Pubmed search

[1]

[2]

Carboxylesterase 2 (intestine, liver), also known as CES2, is a human gene.^[1]

Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood-brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: CES2 carboxylesterase 2 (intestine, liver).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Schwer H, Langmann T, Daig R, et al. (1997). "Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver.". Biochem. Biophys. Res. Commun. 233 (1): 117-20. doi:10.1006/bbrc.1997.6413. PMID 9144407.
Pindel EV, Kedishvili NY, Abraham TL, et al. (1997). "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin.". J. Biol. Chem. 272 (23): 14769-75. PMID 9169443.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Yan B, Matoney L, Yang D (1999). "Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms.". Placenta 20 (7): 599-607. doi:10.1053/plac.1999.0407. PMID 10452915.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.". Am. J. Hum. Genet. 71 (6): 1443-9. PMID 12417987.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Saito S, Iida A, Sekine A, et al. (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population.". J. Hum. Genet. 48 (5): 249-70. doi:10.1007/s10038-003-0021-7. PMID 12721789.
Wu MH, Chen P, Remo BF, et al. (2004). "Characterization of multiple promoters in the human carboxylesterase 2 gene.". Pharmacogenetics 13 (7): 425-35. doi:10.1097/01.fpc.0000054103.48725.db. PMID 12835618.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Marsh S, Xiao M, Yu J, et al. (2005). "Pharmacogenomic assessment of carboxylesterases 1 and 2.". Genomics 84 (4): 661-8. doi:10.1016/j.ygeno.2004.07.008. PMID 15475243.
Wu MH, Chen P, Wu X, et al. (2005). "Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene.". Pharmacogenetics 14 (9): 595-605. PMID 15475733.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Charasson V, Bellott R, Meynard D, et al. (2005). "Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38.". Clin. Pharmacol. Ther. 76 (6): 528-35. doi:10.1016/j.clpt.2004.08.007. PMID 15592324.
Kim SR, Nakamura T, Saito Y, et al. (2005). "Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2).". Drug Metab. Pharmacokinet. 18 (5): 327-32. PMID 15618752.
Fox CA, Sapinoso LM, Zhang H, et al. (2005). "Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas.". Neoplasia 7 (4): 407-16. PMID 15967118.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.