CEP57

From Wikipedia, the free encyclopedia

Centrosomal protein 57kDa

Identifiers

CEP57; PIG8; KIAA0092; TSP57

External IDs

OMIM: 607951 MGI: 1915551 HomoloGene: 8790

Gene ontology
Molecular Function:	• protein binding • fibroblast growth factor binding • protein homodimerization activity
Cellular Component:	• nucleus • cytoplasm • Golgi apparatus • centrosome • microtubule
Biological Process:	• protein import into nucleus, translocation • spermatid development • fibroblast growth factor receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014679 (mRNA)
NP_055494 (protein)

NM_026665 (mRNA)
NP_080941 (protein)

Location

Chr 11: 95.16 - 95.21 Mb

Chr 9: 13.56 - 13.58 Mb

Pubmed search

[1]

[2]

Centrosomal protein 57kDa, also known as CEP57, is a human gene.^[1]

Translokin binds basic fibroblast growth factor (FGF2; MIM 134920) and mediates its nuclear translocation and mitogenic activity (Bossard et al., 2003).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CEP57 centrosomal protein 57kDa.

[edit] Further reading

Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (1): 37–43. PMID 7788527.
Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins.". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bossard C, Laurell H, Van den Berghe L, et al. (2003). "Translokin is an intracellular mediator of FGF-2 trafficking.". Nat. Cell Biol. 5 (5): 433–9. doi:10.1038/ncb979. PMID 12717444.
Kim YS, Nakanishi G, Oudes AJ, et al. (2004). "Tsp57: a novel gene induced during a specific stage of spermatogenesis.". Biol. Reprod. 70 (1): 106–13. doi:10.1095/biolreprod.103.018465. PMID 12954732.
Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling.". Nature 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus.". J. Biochem. Mol. Biol. 37 (6): 741–8. PMID 15607035.