CEP250

From Wikipedia, the free encyclopedia

Centrosomal protein 250kDa

Identifiers

CEP250; CEP2; C-NAP1; MGC88542

External IDs

OMIM: 609689 MGI: 108084 HomoloGene: 38286

Gene ontology
Molecular Function:	• protein kinase binding
Cellular Component:	• centrosome
Biological Process:	• mitotic cell cycle • regulation of centriole-centriole cohesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001035518 (mRNA)
NP_001030595 (protein)

NM_008383 (mRNA)
NP_032409 (protein)

Location

Chr 20: 33.51 - 33.56 Mb

Chr 2: 155.65 - 155.69 Mb

Pubmed search

[1]

[2]

Centrosomal protein 250kDa, also known as CEP250, is a human gene.^[1]

This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Alternately spliced transcript variants encoding different isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: CEP250 centrosomal protein 250kDa.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Faragher AJ, Fry AM (2004). "Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles.". Mol. Biol. Cell 14 (7): 2876–89. doi:10.1091/mbc.E03-02-0108. PMID 12857871.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mayor T, Hacker U, Stierhof YD, Nigg EA (2003). "The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles.". J. Cell. Sci. 115 (Pt 16): 3275–84. PMID 12140259.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Mayor T, Stierhof YD, Tanaka K, et al. (2000). "The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion.". J. Cell Biol. 151 (4): 837–46. PMID 11076968.
Hirsch DS, Pirone DM, Burbelo PD (2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes.". J. Biol. Chem. 276 (2): 875–83. doi:10.1074/jbc.M007039200. PMID 11035016.
Helps NR, Luo X, Barker HM, Cohen PT (2001). "NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1.". Biochem. J. 349 (Pt 2): 509–18. PMID 10880350.
Fry AM, Mayor T, Meraldi P, et al. (1998). "C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2.". J. Cell Biol. 141 (7): 1563–74. PMID 9647649.
Mack GJ, Rees J, Sandblom O, et al. (1998). "Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome.". Arthritis Rheum. 41 (3): 551–8. doi:10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X. PMID 9506584.