Centromere protein E

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Centromere protein E, 312kDa
PDB rendering based on 1t5c.
Available structures: 1t5c
Identifiers
Symbol(s) CENPE; KIF10
External IDs OMIM: 117143 MGI: 1098230 HomoloGene: 20429
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1062 229841
Ensembl ENSG00000138778 ENSMUSG00000045328
Refseq NM_001813 (mRNA)
NP_001804 (protein)		 NM_173762 (mRNA)
NP_776123 (protein)
Location Chr 4: 104.25 - 104.34 Mb Chr 3: 135.15 - 135.21 Mb
Pubmed search [1] [2]

Centromere protein E, 312kDa, also known as CENPE, is a human gene.[1]

Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation.[1]

[edit] References

  1. ^ a b Entrez Gene: CENPE centromere protein E, 312kDa.

[edit] Further reading

  • Yen TJ, Li G, Schaar BT, et al. (1992). "CENP-E is a putative kinetochore motor that accumulates just before mitosis.". Nature 359 (6395): 536–9. doi:10.1038/359536a0. PMID 1406971. 
  • Yen TJ, Compton DA, Wise D, et al. (1991). "CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase.". EMBO J. 10 (5): 1245–54. PMID 2022189. 
  • Testa JR, Zhou JY, Bell DW, Yen TJ (1995). "Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24-->q25 and 1q32-->q41, respectively, by fluorescence in situ hybridization.". Genomics 23 (3): 691–3. doi:10.1006/geno.1994.1558. PMID 7851898. 
  • Thrower DA, Jordan MA, Schaar BT, et al. (1995). "Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor.". EMBO J. 14 (5): 918–26. PMID 7889940. 
  • Wood KW, Sakowicz R, Goldstein LS, Cleveland DW (1997). "CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment.". Cell 91 (3): 357–66. PMID 9363944. 
  • Cooke CA, Schaar B, Yen TJ, Earnshaw WC (1998). "Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase.". Chromosoma 106 (7): 446–55. PMID 9391217. 
  • Zecevic M, Catling AD, Eblen ST, et al. (1998). "Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E.". J. Cell Biol. 142 (6): 1547–58. PMID 9744883. 
  • Chan GK, Schaar BT, Yen TJ (1998). "Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1.". J. Cell Biol. 143 (1): 49–63. PMID 9763420. 
  • Chan GK, Jablonski SA, Sudakin V, et al. (1999). "Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC.". J. Cell Biol. 146 (5): 941–54. PMID 10477750. 
  • Ashar HR, James L, Gray K, et al. (2000). "Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules.". J. Biol. Chem. 275 (39): 30451–7. doi:10.1074/jbc.M003469200. PMID 10852915. 
  • Uren AG, Wong L, Pakusch M, et al. (2001). "Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.". Curr. Biol. 10 (21): 1319–28. PMID 11084331. 
  • Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMID 11337467. 
  • Liu ST, Chan GK, Hittle JC, et al. (2003). "Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores.". Mol. Biol. Cell 14 (4): 1638–51. doi:10.1091/mbc.02-05-0074. PMID 12686615. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
  • Garcia-Saez I, Blot D, Kahn R, Kozielski F (2005). "Crystallization and preliminary crystallographic analysis of the motor domain of human kinetochore-associated protein CENP-E using an automated crystallization procedure.". Acta Crystallogr. D Biol. Crystallogr. 60 (Pt 6): 1158–60. doi:10.1107/S0907444904009564. PMID 15159587. 
  • Tanudji M, Shoemaker J, L'Italien L, et al. (2005). "Gene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delay.". Mol. Biol. Cell 15 (8): 3771–81. doi:10.1091/mbc.E03-07-0482. PMID 15181147. 
  • Garcia-Saez I, Yen T, Wade RH, Kozielski F (2004). "Crystal structure of the motor domain of the human kinetochore protein CENP-E.". J. Mol. Biol. 340 (5): 1107–16. doi:10.1016/j.jmb.2004.05.053. PMID 15236970. 
  • Kurasawa Y, Earnshaw WC, Mochizuki Y, et al. (2005). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation.". EMBO J. 23 (16): 3237–48. doi:10.1038/sj.emboj.7600347. PMID 15297875. 
  • Mao Y, Desai A, Cleveland DW (2005). "Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling.". J. Cell Biol. 170 (6): 873–80. doi:10.1083/jcb.200505040. PMID 16144904. 
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220. 
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