Centrin

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Centrin, also known as caltractin, is a calcium-binding phosphoprotein found in the centrosome of eukaryotes. Centrin is present in the centrioles and pericentriolar lattice[1] [2]

Contents

[edit] Function

Centrin is required for duplication of centrioles.[2] It may also play a role in severing of microtubules by causing calcium-mediated contraction.[3] The majority of centrin in the cell is non-centrosomal whose function is not yet clear.[4]


[edit] Structure

Centrin belongs to the EF-hand superfamily of calcium-binding proteins and has four calcium-binding EF-hands.[5] It has a molecular weight of 20 kDa.[6]

[edit] References

  1. ^ Baron, Greenwood, Bazinet, Salisbury Centrin is a component of the pericentriolar lattice; Biology of the Cell (1992) 76, (383–388)
  2. ^ a b Jeffrey L. Salisbury, Kelly M. Suino, Robert Busby, Margaret Springett; Centrin-2 Is Required for Centriole Duplication in Mammalian Cells; Current Biology, Volume 12, Issue 15, 6 August 2002, Pages 1287-1292; doi:10.1016/S0960-9822(02)01019-9
  3. ^ Uwe Wolfrum,; Centrin in the photoreceptor cells of mammalian retinae; Cell Motility and the Cytoskeleton, Volume 32, Issue 1 , Pages 55 - 64
  4. ^ Anne Paoletti, Mohammed Moudjou, Michel Paintrand, Jeffrey L. Salisbury and Michel Bornens; Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles; Journal of Cell Science 109, 3089-3102 (1996)
  5. ^ Jeffrey L. Satisbury; Centrin, centrosomes, and mitotic spindle poles; Current Opinion in Cell Biology, Volume 7, Issue 1, 1995, Pages 39-45; doi:10.1016/0955-0674(95)80043-3
  6. ^ Yaron Y. Levy, Elaine Y. Lai, Stephen P. Remillard, Matthew B. Heintzelman, Chandler Fulton;Centrin is a conserved protein that forms diverse associations with centrioles and MTOCs in Naegleria and other organisms; Cell Motility and the Cytoskeleton, Volume 33, Issue 4, Pages 298 - 323

[edit] See also

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