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Central Institute for Experimental Animals (CIEA) (実験動物中央研究所) is a research center for experimental animals in Japan. It was founded by Tatsuji Nomura in 1952 with the mission of improving the level of biomedical research.
[edit] Main achievements and ongoing projects
- Establishment of the world first and only monitoring center for experimental animals in 1970. Appointed as an International Council for Laboratory Animal Science (ICLAS) Monitoring Center in 1979.
- Development and establishement of Tg-PVR mouse, in which a human poliovirus receptor gene is introduced, used as a safety testing for oral polio vaccine.
- Establishment of Tg-rasH2 mouse, in which a human proto type c-Ha-ras oncogene is introduced, and evaluation of their practical usefulness. Achieved a high level of accuracy in carcinogenicity testing for drugs and reduced the testing period to six months from conventional two years system.[1]
- Establishment of a severe immunodeficient mouse, NOD/Shi-scid, IL-2Rγnull mouse (NOD/SCID/IL-2Rγnull mouse, NOG mouse) and development of its applications to various animal experiments and testing systems.
[edit] History
- 1952 Founded in Nishitama, Tokyo, Japan
- 1957 Authorized as a non-profit research organization under Ministry of Education, Japan
- 1962 Specific Pathogen Free (SPF) animal production facility was established in Nogawa, Kawasaki, Japan
- 1965 Animal production and supply department was spun off as CLEA Japan, Inc.
- 1966 Preclinical Research Laboratory was established
- 1969 Germ-free animal facility was established
- 1973 Bioscience Research Department was established
- 1976 Organized "The 2nd International Workshop on Nude Mice", Tokyo, Chairman T. Nomura
- 1979 Appointed as ICLAS Monitoring Center
- 1982 Embryological Engineering Laboratory was established
- 1985 Laboratory animal monitoring facilities completed
- 1987 Developmental Engineering Experiment Manual published
- 1988 High priority "Laboratory animal monitoring project" started
- 1991 From Six Mice (History of Central Institute for Experimental Animals) published
- 1992 Laboratory Animal Cryopreservation Facilities completed
- 2001 Center for the Advancement of Health and Biosciences (CAHB) established as a nonprofit organization in the United States
- 2002 Global business development was initiated
- 2005 NOG mouse patent granted
- 2006 Tatsuji Nomura becomes Chairman of the Board of Directors of CIEA
- 2006 Organized "The 1st International Workshop on Humanized Mice", Tokyo, Chairman T. Nomura
[edit] External links
[edit] References
- ^ James MacDonald and et.al. (2004). "The Utility of Genetically Modified Mouse Assays for Identifying Human Carcinogens: A Basic Understanding and Path Forward". Toxicological Sciences 77: 188–194. doi:10.1093/toxsci/kfh037.
