CENTG1

From Wikipedia, the free encyclopedia

Centaurin, gamma 1

PDB rendering based on 2bmj.

Available structures: 2bmj, 2iwr

Identifiers

Symbol(s)

CENTG1; AGAP2; FLJ16430; GGAP2; KIAA0167; PIKE

External IDs

OMIM: 605476 HomoloGene: 86981

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • GTPase activator activity • GTP binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• signal transduction • small GTPase mediated signal transduction • protein transport • regulation of GTPase activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

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Refseq

NM_014770 (mRNA)
NP_055585 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 12: 56.41 - 56.42 Mb

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Pubmed search

[1]

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Centaurin, gamma 1, also known as CENTG1, is a human gene.^[1]

[edit] References

^ Entrez Gene: CENTG1 centaurin, gamma 1.

[edit] Further reading

Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 3 (1): 17–24. PMID 8724849.
Elkahloun AG, Krizman DB, Wang Z, et al. (1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.". Genomics 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850.
Ye K, Hurt KJ, Wu FY, et al. (2001). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N.". Cell 103 (6): 919–30. PMID 11136977.
Ye K, Aghdasi B, Luo HR, et al. (2002). "Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE.". Nature 415 (6871): 541–4. doi:10.1038/415541a. PMID 11823862.
Nie Z, Stanley KT, Stauffer S, et al. (2003). "AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton.". J. Biol. Chem. 277 (50): 48965–75. doi:10.1074/jbc.M202969200. PMID 12388557.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Xia C, Ma W, Stafford LJ, et al. (2003). "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.". Mol. Cell. Biol. 23 (7): 2476–88. PMID 12640130.
Rong R, Ahn JY, Huang H, et al. (2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ahn JY, Rong R, Kroll TG, et al. (2004). "PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion.". J. Biol. Chem. 279 (16): 16441–51. doi:10.1074/jbc.M312175200. PMID 14761976.
Ahn JY, Hu Y, Kroll TG, et al. (2004). "PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt.". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 6993–8. doi:10.1073/pnas.0400921101. PMID 15118108.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Nie Z, Fei J, Premont RT, Randazzo PA (2005). "The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3.". J. Cell. Sci. 118 (Pt 15): 3555–66. doi:10.1242/jcs.02486. PMID 16079295.
Knobbe CB, Trampe-Kieslich A, Reifenberger G (2005). "Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas.". Neuropathol. Appl. Neurobiol. 31 (5): 486–90. doi:10.1111/j.1365-2990.2005.00660.x. PMID 16150119.
Hu Y, Liu Z, Ye K (2006). "Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings.". Proc. Natl. Acad. Sci. U.S.A. 102 (46): 16853–8. doi:10.1073/pnas.0507365102. PMID 16263930.
Tang X, Feng Y, Ye K (2007). "Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival.". Cell Death Differ. 14 (2): 368–77. doi:10.1038/sj.cdd.4402011. PMID 16841086.
Soundararajan M, Yang X, Elkins JM, et al. (2007). "The centaurin gamma-1 GTPase-like domain functions as an NTPase.". Biochem. J. 401 (3): 679–88. doi:10.1042/BJ20060555. PMID 17037982.
Werden SJ, Barrett JW, Wang G, et al. (2007). "M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A.". J. Virol. 81 (5): 2340–8. doi:10.1128/JVI.01310-06. PMID 17151107.
Liu X, Hu Y, Hao C, et al. (2007). "PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion.". Oncogene 26 (34): 4918–27. doi:10.1038/sj.onc.1210290. PMID 17297440.
Dunphy JL, Ye K, Casanova JE (2007). "Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2.". Traffic 8 (6): 661–72. doi:10.1111/j.1600-0854.2007.00561.x. PMID 17461797.