CENTD2

From Wikipedia, the free encyclopedia

Centaurin, delta 2

Identifiers

CENTD2; ARAP1; KIAA0782

External IDs

OMIM: 606646 MGI: 1916960 HomoloGene: 12326

Gene ontology
Molecular Function:	• Rho GTPase activator activity • protein binding • phosphatidylinositol-3,4,5-triphosphate binding • ARF GTPase activator activity • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • Golgi apparatus
Biological Process:	• signal transduction • regulation of cell shape • actin filament reorganization during cell cycle • regulation of GTPase activity • positive regulation of Cdc42 GTPase activity • regulation of cell motility • positive regulation of filopodium formation • negative regulation of stress fiber formation

Orthologs

Human

Mouse

n/a

Refseq

NM_001040118 (mRNA)
NP_001035207 (protein)

NM_001040111 (mRNA)
NP_001035200 (protein)

Location

n/a

Chr 7: 101.25 - 101.29 Mb

Pubmed search

[1]

[2]

Centaurin, delta 2, also known as CENTD2, is a human gene.^[1]

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. The RHO-GAP activity may mediate cell rounding and loss of stress fibers. At least three transcript variants encoding different isoforms have been found for this gene, but the full-length natures of all variants have not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: CENTD2 centaurin, delta 2.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. PMID 9872452.
Krugmann S, Anderson KE, Ridley SH, et al. (2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.". Mol. Cell 9 (1): 95–108. PMID 11804589.
Miura K, Jacques KM, Stauffer S, et al. (2002). "ARAP1: a point of convergence for Arf and Rho signaling.". Mol. Cell 9 (1): 109–19. PMID 11804590.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus.". J. Biochem. Mol. Biol. 37 (6): 741–8. PMID 15607035.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.