Cellobiose dehydrogenase (acceptor)

From Wikipedia, the free encyclopedia

In enzymology, a cellobiose dehydrogenase (acceptor) (EC 1.1.99.18) is an enzyme that catalyzes the chemical reaction

cellobiose + acceptor $\rightleftharpoons$ cellobiono-1,5-lactone + reduced acceptor

Thus, the two substrates of this enzyme are cellobiose and acceptor, whereas its two products are cellobiono-1,5-lactone and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is cellobiose:acceptor 1-oxidoreductase. Other names in common use include cellobiose dehydrogenase, cellobiose oxidoreductase, Phanerochaete chrysosporium cellobiose oxidoreductase, CBOR, cellobiose oxidase, cellobiose:oxygen 1-oxidoreductase, CDH, and cellobiose:(acceptor) 1-oxidoreductase. It employs one cofactor, FAD.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1NAA and 1PL3.

[edit] References

IUBMB entry for 1.1.99.18
BRENDA references for 1.1.99.18 (Recommended.)
PubMed references for 1.1.99.18
PubMed Central references for 1.1.99.18
Google Scholar references for 1.1.99.18
Coudray MR, Canevascini G, Meier H (1982). "Characterization of a cellobiose dehydrogenase in the cellulolytic fungus Sporotrichum (Chrysosporium) thermophile". Biochem. J. 203: 277–84. PMID 7103940.
Dekker RFH (1980). "Induction and characterization of a cellobiose dehydrogenase produced by a species of Monilia". J. Gen. Microbiol. 120: 309–316.
Dekker RFH (1988). "Cellobiose dehydrogenase produced by Monilia sp". Methods Enzymol. 160: 454–463.
Habu N, Samejima M, Dean JF, Eriksson KE (1993). "Release of the FAD domain from cellobiose oxidase by proteases from cellulolytic cultures of Phanerochaete chrysosporium". FEBS. Lett. 327: 161–4. PMID 8392950.
Baminger U, Subramaniam SS, Renganathan V, Haltrich D (2001). "Purification and characterization of cellobiose dehydrogenase from the plant pathogen Sclerotium (Athelia) rolfsii". Appl. Environ. Microbiol. 67: 1766–74. PMID 11282631.
Hallberg BM, Henriksson G, Pettersson G, Divne C (2002). "Crystal structure of the flavoprotein domain of the extracellular flavocytochrome cellobiose dehydrogenase". J. Mol. Biol. 315: 421–34. PMID 11786022.
Ayers AR, Ayers SB, Eriksson KE (1978). "Cellobiose oxidase, purification and partial characterization of a hemoprotein from Sporotrichum pulverulentum". Eur. J. Biochem. 90: 171–81. PMID 710416.
Ayers AR, Eriksson KE (1982). "Cellobiose oxidase from Sporotrichum pulverulentum". Methods. Enzymol. 89 Pt D: 129–35. PMID 7144569.
Mason MG, Nicholls P, Divne C, Hallberg BM, Henriksson G, Wilson MT (2003). "The heme domain of cellobiose oxidoreductase: a one-electron reducing system". Biochim. Biophys. Acta. 1604: 47–54. PMID 12686420.