CDP-paratose 2-epimerase

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In enzymology, a CDP-paratose 2-epimerase (EC 5.1.3.10) is an enzyme that catalyzes the chemical reaction

CDP-3,6-dideoxy-D-glucose $\rightleftharpoons$ CDP-3,6-dideoxy-D-mannose

Hence, this enzyme has one substrate, CDP-3,6-dideoxy-D-glucose, and one product, CDP-3,6-dideoxy-D-mannose.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is CDP-3,6-dideoxy-D-glucose 2-epimerase. Other names in common use include CDP-paratose epimerase, cytidine diphosphoabequose epimerase, cytidine diphosphodideoxyglucose epimerase, cytidine diphosphoparatose epimerase, and cytidine diphosphate paratose-2-epimerase. It is also incorrectly known as CDP-abequose epimerase, and CDP-D-abequose 2-epimerase. This enzyme participates in starch and sucrose metabolism. It employs one cofactor, NAD+.

[edit] References

IUBMB entry for 5.1.3.10
BRENDA references for 5.1.3.10 (Recommended.)
PubMed references for 5.1.3.10
PubMed Central references for 5.1.3.10
Google Scholar references for 5.1.3.10
Matsuhashi S (1966). "Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. II Reversible 2-epimerization of cytidine diphosphate paratose". J. Biol. Chem. 241: 4275–82. PMID 5924649.
Liu HW, Thorson JS (1994). "Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria". Annu. Rev. Microbiol. 48: 223–56. doi:10.1146/annurev.mi.48.100194.001255. PMID 7826006.