CDP-glucose 4,6-dehydratase

From Wikipedia, the free encyclopedia

In enzymology, a CDP-glucose 4,6-dehydratase (EC 4.2.1.45) is an enzyme that catalyzes the chemical reaction

CDP-glucose $\rightleftharpoons$ CDP-4-dehydro-6-deoxy-D-glucose + H₂O

Hence, this enzyme has one substrate, CDP-glucose, and two products, CDP-4-dehydro-6-deoxy-D-glucose and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming). Other names in common use include cytidine diphosphoglucose oxidoreductase, and CDP-glucose 4,6-hydro-lyase. This enzyme participates in starch and sucrose metabolism. It employs one cofactor, NAD+.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1RKX and 1WVG.

[edit] References

IUBMB entry for 4.2.1.45
BRENDA references for 4.2.1.45 (Recommended.)
PubMed references for 4.2.1.45
PubMed Central references for 4.2.1.45
Google Scholar references for 4.2.1.45
Hey AE, Elbein AD (1966). "Biosynthesis of tyvelose. The purification and properties of cytidine diphosphate D-glucose oxidoreductase". J. Biol. Chem. 241: 5473–8. PMID 4380946.
Matsuhashi S, Matsuhashi M, Brown JG, Strominger JL (1966). "Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 3 Cytidine diphosphate D-glucose oxidoreductase". J. Biol. Chem. 241: 4283–7. PMID 4288651.
Melo A, Elliott WH, Glaser L (1968). "The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase". J. Biol. Chem. 243: 1467–74. PMID 4869560.