CDP-diacylglycerol-inositol 3-phosphatidyltransferase

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In enzymology, a CDP-diacylglycerol-inositol 3-phosphatidyltransferase (EC 2.7.8.11) is an enzyme that catalyzes the chemical reaction

CDP-diacylglycerol + myo-inositol $\rightleftharpoons$ CMP + phosphatidyl-1D-myo-inositol

Thus, the two substrates of this enzyme are CDP-diacylglycerol and myo-inositol, whereas its two products are CMP and phosphatidyl-1D-myo-inositol.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase. Other names in common use include CDP-diglyceride-inositol phosphatidyltransferase, phosphatidylinositol synthase, CDP-diacylglycerol-inositol phosphatidyltransferase, CDP-diglyceride:inositol transferase, cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol, 3-phosphatidyltransferase, CDP-DG:inositol transferase, cytidine diphosphodiglyceride-inositol phosphatidyltransferase, CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase, CDP-diglyceride-inositol transferase, cytidine diphosphoglyceride-inositol phosphatidyltransferase, and cytidine diphosphoglyceride-inositol transferase. This enzyme participates in glycerophospholipid metabolism and phosphatidylinositol signaling system.

[edit] References

IUBMB entry for 2.7.8.11
BRENDA references for 2.7.8.11 (Recommended.)
PubMed references for 2.7.8.11
PubMed Central references for 2.7.8.11
Google Scholar references for 2.7.8.11
Bleasdale JE, Wallis P, MacDonald PC, Johnston JM (1979). "Characterization of the forward and reverse reactions catalyzed by CDP-diacylglycerol:inositol transferase in rabbit lung tissue". Biochim. Biophys. Acta. 575: 135–47. PMID 41587.
Prottey C, Hawthorne JN (1967). "The biosynthesis of phosphatidic acid and phosphatidylinositol in mammalian pancreas". Biochem. J. 105: 379–92. PMID 4293959.
Salway JG, Harwood JL, Kai M, White GL, Haworne JN (1968). "Enzymes of phosphoinositide metabolism during rat brain development". J. Neurochem. 15: 221–6. doi:10.1111/j.1471-4159.1968.tb06200.x. PMID 4295616.
Takenawa T, Egawa K (1977). "CDP-diglyceride:inositol transferase from rat liver. Purification and properties". J. Biol. Chem. 252: 5419–23. PMID 18462.