CDP-4-dehydro-6-deoxyglucose reductase

From Wikipedia, the free encyclopedia

In enzymology, a CDP-4-dehydro-6-deoxyglucose reductase (EC 1.17.1.1) is an enzyme that catalyzes the chemical reaction

CDP-4-dehydro-3,6-dideoxy-D-glucose + NAD(P)+ + H₂O $\rightleftharpoons$ CDP-4-dehydro-6-deoxy-D-glucose + NAD(P)H + H⁺

The 4 substrates of this enzyme are CDP-4-dehydro-3,6-dideoxy-D-glucose, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are CDP-4-dehydro-6-deoxy-D-glucose, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 group with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase. Other names in common use include CDP-4-keto-6-deoxyglucose reductase, cytidine diphospho-4-keto-6-deoxy-D-glucose reductase, cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase, CDP-4-keto-deoxy-glucose reductase, CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system, and NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase. This enzyme participates in starch and sucrose metabolism.

[edit] References

IUBMB entry for 1.17.1.1
BRENDA references for 1.17.1.1 (Recommended.)
PubMed references for 1.17.1.1
PubMed Central references for 1.17.1.1
Google Scholar references for 1.17.1.1
Pape H, Strominger JL (1969). "Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. V Partial purification of the two protein components required for introduction of the 3-deoxy group". J. Biol. Chem. 244: 3598–604. PMID 4389672.
Rubenstein PA, Strominger JL (1974). "Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 8 Mechanistic roles of enzyme E-1 and pyridoxamine 5'-phosphate in the formation of cytidine diphosphate-4-keto-3,6-dideoxy-D-glucose from cytidine diphosphate-4-keto-6-deoxy-D-glucose". J. Biol. Chem. 249: 3776–81. PMID 4152100.
Liu HW, Thorson JS (1994). "Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria". Annu. Rev. Microbiol. 48: 223–56. doi:10.1146/annurev.mi.48.100194.001255. PMID 7826006.