CDON

From Wikipedia, the free encyclopedia

Cdon homolog (mouse)

Identifiers

CDON; CDO; MGC111524; ORCAM

External IDs

OMIM: 608707 MGI: 1926387 HomoloGene: 22996

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• cell fate specification • cell adhesion • smoothened signaling pathway • myoblast fusion • embryonic body morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001133286 (mRNA)
XP_001133286 (protein)

NM_021339 (mRNA)
NP_067314 (protein)

Location

Chr 11: 125.33 - 125.44 Mb

Chr 9: 35.2 - 35.25 Mb

Pubmed search

[1]

[2]

Cdon homolog (mouse), also known as CDON, is a human gene.^[1]

CDON and BOC (MIM 608708) are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII; see MIM 135600) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CDON Cdon homolog (mouse).

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Wegorzewska M, Krauss RS, Kang JS (2003). "Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD.". Mol. Carcinog. 37 (1): 1-4. doi:10.1002/mc.10121. PMID 12720294.
Kang JS, Feinleib JL, Knox S, et al. (2003). "Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation.". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 3989-94. doi:10.1073/pnas.0736565100. PMID 12634428.
Cole F, Krauss RS (2003). "Microform holoprosencephaly in mice that lack the Ig superfamily member Cdon.". Curr. Biol. 13 (5): 411-5. PMID 12620190.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kang JS, Mulieri PJ, Hu Y, et al. (2002). "BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation.". EMBO J. 21 (1-2): 114-24. doi:10.1093/emboj/21.1.114. PMID 11782431.
Kang JS, Gao M, Feinleib JL, et al. (1997). "CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family.". J. Cell Biol. 138 (1): 203-13. PMID 9214393.