CDK5RAP1

From Wikipedia, the free encyclopedia

CDK5 regulatory subunit associated protein 1

Identifiers

CDK5RAP1; C20orf34; C42; CDK5RAP1.3; CDK5RAP1.4; CGI-05; HSPC167

External IDs

OMIM: 608200 MGI: 1914221 HomoloGene: 9502

Gene ontology
Molecular Function:	• catalytic activity • iron ion binding • protein binding • neuronal Cdc2-like kinase binding • metal ion binding • 4 iron, 4 sulfur cluster binding
Cellular Component:	• cellular_component
Biological Process:	• brain development • cell proliferation • regulation of neuron differentiation • negative regulation of cyclin-dependent protein kinase activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016082 (mRNA)
NP_057166 (protein)

NM_025876 (mRNA)
NP_080152 (protein)

Location

Chr 20: 31.41 - 31.45 Mb

Chr 2: 154.03 - 154.06 Mb

Pubmed search

[1]

[2]

CDK5 regulatory subunit associated protein 1, also known as CDK5RAP1, is a human gene.^[1]

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. Multiple transcript variants exist for this gene, but the full-length natures of only two have been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: CDK5RAP1 CDK5 regulatory subunit associated protein 1.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Ching YP, Qi Z, Wang JH (2000). "Cloning of three novel neuronal Cdk5 activator binding proteins.". Gene 242 (1-2): 285–94. PMID 10721722.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. PMID 10810093.
Wang X, Ching YP, Lam WH, et al. (2000). "Identification of a common protein association region in the neuronal Cdk5 activator.". J. Biol. Chem. 275 (41): 31763–9. doi:10.1074/jbc.M004358200. PMID 10915792.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Ching YP, Pang AS, Lam WH, et al. (2002). "Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor.". J. Biol. Chem. 277 (18): 15237–40. doi:10.1074/jbc.C200032200. PMID 11882646.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Zou X, Ji C, Jin F, et al. (2005). "Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1.". Genes Genet. Syst. 79 (3): 177–82. PMID 15329498.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.