CDH6

From Wikipedia, the free encyclopedia

Cadherin 6, type 2, K-cadherin (fetal kidney)

Identifiers

CDH6; KCAD

External IDs

OMIM: 603007 MGI: 107435 HomoloGene: 21027

Gene ontology
Molecular Function:	• calcium ion binding • protein binding
Cellular Component:	• plasma membrane • integral to membrane
Biological Process:	• cell adhesion • homophilic cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004932 (mRNA)
NP_004923 (protein)

NM_007666 (mRNA)
NP_031692 (protein)

Location

Chr 5: 31.23 - 31.37 Mb

Chr 15: 12.98 - 13.04 Mb

Pubmed search

[1]

[2]

Cadherin 6, type 2, K-cadherin (fetal kidney), also known as CDH6, is a human gene.^[1]

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.^[1]

[edit] References

^ ^a ^b Entrez Gene: CDH6 cadherin 6, type 2, K-cadherin (fetal kidney).

[edit] Further reading

MacCalman CD, Getsios S, Chen GT (1998). "Type 2 cadherins in the human endometrium and placenta: their putative roles in human implantation and placentation.". Am. J. Reprod. Immunol. 39 (2): 96–107. PMID 9506208.
Suzuki S, Sano K, Tanihara H (1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.". Cell Regul. 2 (4): 261–70. PMID 2059658.
Shimoyama Y, Gotoh M, Terasaki T, et al. (1995). "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells.". Cancer Res. 55 (10): 2206–11. PMID 7743525.
Paul R, Ewing CM, Robinson JC, et al. (1997). "Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma.". Cancer Res. 57 (13): 2741–8. PMID 9205085.
Getsios S, Chen GT, Stephenson MD, et al. (1998). "Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium.". Dev. Dyn. 211 (3): 238–47. doi:10.1002/(SICI)1097-0177(199803)211:3<238::AID-AJA5>3.0.CO;2-I. PMID 9520111.
Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
Chalmers IJ, Höfler H, Atkinson MJ (1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma.". Genomics 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
Shimoyama Y, Takeda H, Yoshihara S, et al. (1999). "Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin.". J. Biol. Chem. 274 (17): 11987–94. PMID 10207020.
Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.". Biochem. J. 349 (Pt 1): 159–67. PMID 10861224.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.