CDH15

From Wikipedia, the free encyclopedia

Cadherin 15, M-cadherin (myotubule)

Identifiers

CDH15; MCAD; CDH3; CDH14; CDHM

External IDs

OMIM: 114019 MGI: 106672 HomoloGene: 3622

Gene ontology
Molecular Function:	• calcium ion binding • protein binding
Cellular Component:	• plasma membrane • integral to membrane
Biological Process:	• cell adhesion • homophilic cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004933 (mRNA)
NP_004924 (protein)

NM_007662 (mRNA)
NP_031688 (protein)

Location

Chr 16: 87.77 - 87.79 Mb

Chr 8: 125.73 - 125.75 Mb

Pubmed search

[1]

[2]

Cadherin 15, M-cadherin (myotubule), also known as CDH15, is a human gene.^[1]

This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.^[1]

[edit] References

^ ^a ^b Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule).

[edit] Further reading

Kaupmann K, Becker-Follmann J, Scherer G, et al. (1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species.". Genomics 14 (2): 488–90. PMID 1427864.
Donalies M, Cramer M, Ringwald M, Starzinski-Powitz A (1991). "Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells.". Proc. Natl. Acad. Sci. U.S.A. 88 (18): 8024–8. PMID 1840697.
Bornemann A, Schmalbruch H (1994). "Immunocytochemistry of M-cadherin in mature and regenerating rat muscle.". Anat. Rec. 239 (2): 119–25. doi:10.1002/ar.1092390202. PMID 8059975.
Shibata T, Shimoyama Y, Gotoh M, Hirohashi S (1997). "Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning.". J. Biol. Chem. 272 (8): 5236–40. PMID 9030594.
Kuch C, Winnekendonk D, Butz S, et al. (1997). "M-cadherin-mediated cell adhesion and complex formation with the catenins in myogenic mouse cells.". Exp. Cell Res. 232 (2): 331–8. doi:10.1006/excr.1997.3519. PMID 9168809.
Shimoyama Y, Shibata T, Kitajima M, Hirohashi S (1998). "Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin.". J. Biol. Chem. 273 (16): 10011–8. PMID 9545347.
Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.". Biochem. J. 349 (Pt 1): 159–67. PMID 10861224.
Kaufmann U, Zuppinger C, Waibler Z, et al. (2001). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions.". J. Cell. Sci. 113 ( Pt 22): 4121–35. PMID 11058098.
Meigs TE, Fields TA, McKee DD, Casey PJ (2001). "Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 519–24. doi:10.1073/pnas.021350998. PMID 11136230.
Hollnagel A, Grund C, Franke WW, Arnold HH (2002). "The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration.". Mol. Cell. Biol. 22 (13): 4760–70. PMID 12052883.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kang JS, Feinleib JL, Knox S, et al. (2003). "Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation.". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 3989–94. doi:10.1073/pnas.0736565100. PMID 12634428.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.