CDH12

From Wikipedia, the free encyclopedia

Cadherin 12, type 2 (N-cadherin 2)

Identifiers

CDH12; CDHB; FLJ34857

External IDs

OMIM: 600562 MGI: 109503 HomoloGene: 37873

Gene ontology
Molecular Function:	• calcium ion binding • protein binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• cell adhesion • homophilic cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004061 (mRNA)
NP_004052 (protein)

NM_001008420 (mRNA)
NP_001008420 (protein)

Location

Chr 5: 21.79 - 22.89 Mb

Chr 15: 21.06 - 21.53 Mb

Pubmed search

[1]

[2]

Cadherin 12, type 2 (N-cadherin 2), also known as CDH12, is a human gene.^[1]

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.^[1]

[edit] References

^ ^a ^b Entrez Gene: CDH12 cadherin 12, type 2 (N-cadherin 2).

[edit] Further reading

Weissenbach J, Gyapay G, Dib C, et al. (1992). "A second-generation linkage map of the human genome.". Nature 359 (6398): 794-801. doi:10.1038/359794a0. PMID 1436057.
Suzuki S, Sano K, Tanihara H (1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.". Cell Regul. 2 (4): 261-70. PMID 2059658.
Gyapay G, Morissette J, Vignal A, et al. (1994). "The 1993-94 Généthon human genetic linkage map.". Nat. Genet. 7 (2 Spec No): 246-339. doi:10.1038/ng0694supp-246. PMID 7545953.
Selig S, Bruno S, Scharf JM, et al. (1995). "Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene.". Proc. Natl. Acad. Sci. U.S.A. 92 (9): 3702-6. PMID 7731968.
Tanihara H, Sano K, Heimark RL, et al. (1995). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.". Cell Adhes. Commun. 2 (1): 15-26. PMID 7982033.
Selig S, Lidov HG, Bruno SA, et al. (1997). "Molecular characterization of Br-cadherin, a developmentally regulated, brain-specific cadherin.". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2398-403. PMID 9122206.
Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.". Genomics 49 (3): 467-71. doi:10.1006/geno.1998.5281. PMID 9615235.
Chalmers IJ, Höfler H, Atkinson MJ (1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma.". Genomics 57 (1): 160-3. doi:10.1006/geno.1998.5717. PMID 10191097.
Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.". Biochem. J. 349 (Pt 1): 159-67. PMID 10861224.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.