CDC2L1

From Wikipedia, the free encyclopedia

Cell division cycle 2-like 1 (PITSLRE proteins)

Identifiers

CDC2L1; CDK11-p110; CDK11-p46; CDK11-p58; CLK-1; PK58; p58; p58CDC2L1; p58CLK-1; CDC2L3; MGC131975; PITSLRE; p58GTA

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• regulation of progression through cell cycle • regulation of cell growth • regulation of transcription, DNA-dependent • protein amino acid phosphorylation • apoptosis • cell cycle • mitosis • cell proliferation • regulation of mRNA processing • cell division

Orthologs

Human

Mouse

Entrez

984

n/a

Refseq

NM_001787 (mRNA)
NP_001778 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Cell division cycle 2-like 1 (PITSLRE proteins), also known as CDC2L1, is a human gene.^[1]

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: CDC2L1 cell division cycle 2-like 1 (PITSLRE proteins).

[edit] Further reading

Eipers PG, Lahti JM, Kidd VJ (1992). "Structure and expression of the human p58clk-1 protein kinase chromosomal gene.". Genomics 13 (3): 613–21. PMID 1639388.
Eipers PG, Barnoski BL, Han J, et al. (1992). "Localization of the expressed human p58 protein kinase chromosomal gene to chromosome 1p36 and a highly related sequence to chromosome 15.". Genomics 11 (3): 621–9. PMID 1774066.
Bunnell BA, Heath LS, Adams DE, et al. (1990). "Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle.". Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7467–71. PMID 2217177.
White PS, Maris JM, Beltinger C, et al. (1995). "A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3.". Proc. Natl. Acad. Sci. U.S.A. 92 (12): 5520–4. PMID 7777541.
Lahti JM, Valentine M, Xiang J, et al. (1994). "Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma.". Nat. Genet. 7 (3): 370–5. doi:10.1038/ng0794-370. PMID 7920654.
Xiang J, Lahti JM, Grenet J, et al. (1994). "Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms.". J. Biol. Chem. 269 (22): 15786–94. PMID 8195233.
Beyaert R, Kidd VJ, Cornelis S, et al. (1997). "Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor.". J. Biol. Chem. 272 (18): 11694–7. PMID 9115219.
Loyer P, Trembley JH, Lahti JM, Kidd VJ (1998). "The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo.". J. Cell. Sci. 111 ( Pt 11): 1495–506. PMID 9580558.
Tang D, Gururajan R, Kidd VJ (1998). "Phosphorylation of PITSLRE p110 isoforms accompanies their processing by caspases during Fas-mediated cell death.". J. Biol. Chem. 273 (26): 16601–7. PMID 9632733.
Gururajan R, Lahti JM, Grenet J, et al. (1998). "Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2.". Genome Res. 8 (9): 929–39. PMID 9750192.
Cornelis S, Bruynooghe Y, Denecker G, et al. (2000). "Identification and characterization of a novel cell cycle-regulated internal ribosome entry site.". Mol. Cell 5 (4): 597–605. PMID 10882096.
Trembley JH, Hu D, Hsu LC, et al. (2002). "PITSLRE p110 protein kinases associate with transcription complexes and affect their activity.". J. Biol. Chem. 277 (4): 2589–96. doi:10.1074/jbc.M109755200. PMID 11709559.
Zhang S, Cai M, Zhang S, et al. (2002). "Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3.". J. Biol. Chem. 277 (38): 35314–22. doi:10.1074/jbc.M202179200. PMID 12082095.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hu D, Mayeda A, Trembley JH, et al. (2003). "CDK11 complexes promote pre-mRNA splicing.". J. Biol. Chem. 278 (10): 8623–9. doi:10.1074/jbc.M210057200. PMID 12501247.
Chen S, Yin X, Zhu X, et al. (2003). "The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis.". J. Biol. Chem. 278 (22): 20029–36. doi:10.1074/jbc.M300818200. PMID 12624090.
Mikolajczyk M, Shi J, Vaillancourt RR, et al. (2003). "The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM.". Biochem. Biophys. Res. Commun. 310 (1): 14–8. PMID 14511641.
de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.". J. Biol. Chem. 279 (6): 4612–24. doi:10.1074/jbc.M310794200. PMID 14623875.
Sachs NA, Vaillancourt RR (2004). "Cyclin-dependent kinase 11p110 and casein kinase 2 (CK2) inhibit the interaction between tyrosine hydroxylase and 14-3-3.". J. Neurochem. 88 (1): 51–62. PMID 14675149.
Yang L, Li N, Wang C, et al. (2004). "Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells.". J. Biol. Chem. 279 (12): 11639–48. doi:10.1074/jbc.M312895200. PMID 14684736.