CD98
From Wikipedia, the free encyclopedia
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
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Identifiers | |
Symbol | SLC3A2 |
Alt. Symbols | MDU1, 4T2HC, 4F2, NACAE |
Entrez | 6520 |
HUGO | 11026 |
OMIM | 158070 |
RefSeq | NM_001013251 |
UniProt | P08195 |
Other data | |
Locus | Chr. 11 q12-q22 |
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
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Identifiers | |
Symbol | SLC7A5 |
Alt. Symbols | LAT1, E16, D16S469E, MPE16, CD98 |
Entrez | 8140 |
HUGO | 11063 |
OMIM | 600182 |
RefSeq | NM_003486 |
UniProt | Q01650 |
Other data | |
Locus | Chr. 16 q24.3 |
CD98 is a glycoprotein[1][2] that comprises the light subunit of the Large neutral Amino acid Transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports neutral branched (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids.[3] LAT is highly expressed in brain capillaries (which form the blood brain barrier) relative to other tissues.[3]
Functional LAT1 transporters are comprised of two proteins encoded by two distinct genes:
- 4F2hc heavy subunit protein encoded by the SLC3A2 gene [4]
- CD98 light subunit protein encoded by the SLC7A5 gene[5]
[edit] See also
[edit] References
- ^ Kucharzik T, Lugering A, Yan Y, Driss A, Charrier L, Sitaraman S, Merlin D (2005). "Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation". Lab. Invest. 85 (7): 932–41. doi: . PMID 15880135.
- ^ Lemaître G, Gonnet F, Vaigot P, Gidrol X, Martin MT, Tortajada J, Waksman G (2005). "CD98, a novel marker of transient amplifying human keratinocytes". Proteomics 5 (14): 3637–45. doi: . PMID 16097038.
- ^ a b Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM (1999). "Selective expression of the large neutral amino acid transporter at the blood-brain barrier". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 12079–84. doi: . PMID 10518579.
- ^ Palacin M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflugers Arch 447 (5): 490–494. doi: . PMID 14770309.
- ^ Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters". Pflugers Arch 447 (5): 532–542. doi: . PMID 14770310.
[edit] External links
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