CD86

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CD86 molecule
PDB rendering based on 1i85.
Available structures: 1i85, 1ncn
Identifiers
Symbol(s)	CD86; B7-2; B70; CD28LG2; LAB72; MGC34413
External IDs	OMIM: 601020 MGI: 101773 HomoloGene: 10443
Gene ontology Molecular Function: • protein binding • coreceptor activity • transcription activator activity Cellular Component: • plasma membrane • external side of plasma membrane • integral to membrane Biological Process: • immune response • cell-cell signaling • positive regulation of cell proliferation • T cell activation • positive regulation of lymphotoxin A biosynthetic process • positive regulation of interleukin-2 biosynthetic process • positive regulation of interleukin-4 biosynthetic process • positive regulation of T-helper 2 cell differentiation • positive regulation of transcription
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	942	12524
Ensembl	ENSG00000114013	ENSMUSG00000022901
Uniprot	P42081	Q3T9F8
Refseq	NM_006889 (mRNA) NP_008820 (protein)	NM_019388 (mRNA) NP_062261 (protein)
Location	Chr 3: 123.26 - 123.32 Mb	Chr 16: 36.52 - 36.59 Mb
Pubmed search	[1]	[2]

The protein CD86 (Cluster of Differentiation 86) is a molecule which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.2. Its principal mode of action is by binding to CD28. Along with CD80, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells.

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.^[1]

[edit] See also

• Cluster of differentiation

[edit] References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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