CD79B
From Wikipedia, the free encyclopedia
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CD79b molecule, immunoglobulin-associated beta
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| Identifiers | ||||||||||||||
| Symbol(s) | CD79B; B29; IGB | |||||||||||||
| External IDs | OMIM: 147245 MGI: 96431 HomoloGene: 521 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 974 | 15985 | ||||||||||||
| Ensembl | ENSG00000007312 | ENSMUSG00000040592 | ||||||||||||
| Uniprot | P40259 | Q4FJP4 | ||||||||||||
| Refseq | NM_000626 (mRNA) NP_000617 (protein) |
NM_008339 (mRNA) NP_032365 (protein) |
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| Location | Chr 17: 59.36 - 59.36 Mb | Chr 11: 106.13 - 106.13 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene.[1]
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Reth M (1992). "Antigen receptors on B lymphocytes.". Annu. Rev. Immunol. 10: 97–121. doi:. PMID 1591006.
- Müller B, Cooper L, Terhorst C (1992). "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29.". Eur. J. Immunol. 22 (6): 1621–5. PMID 1534761.
- Lankester AC, van Schijndel GM, Cordell JL, et al. (1994). "CD5 is associated with the human B cell antigen receptor complex.". Eur. J. Immunol. 24 (4): 812–6. PMID 7512031.
- Vasile S, Coligan JE, Yoshida M, Seon BK (1994). "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex.". Mol. Immunol. 31 (6): 419–27. PMID 7514267.
- Brown VK, Ogle EW, Burkhardt AL, et al. (1994). "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45.". J. Biol. Chem. 269 (25): 17238–44. PMID 7516335.
- Rowley RB, Burkhardt AL, Chao HG, et al. (1995). "Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation.". J. Biol. Chem. 270 (19): 11590–4. PMID 7538118.
- Pani G, Kozlowski M, Cambier JC, et al. (1995). "Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.". J. Exp. Med. 181 (6): 2077–84. PMID 7539038.
- Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29).". Immunol. Lett. 44 (2-3): 97–103. PMID 7541024.
- Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells.". J. Biol. Chem. 270 (45): 27072–8. PMID 7592958.
- Hashimoto S, Chiorazzi N, Gregersen PK (1995). "Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells.". Mol. Immunol. 32 (9): 651–9. PMID 7643857.
- Hashimoto S, Chiorazzi N, Gregersen PK (1994). "The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism.". Immunogenetics 40 (2): 145–9. PMID 7913081.
- Gold MR, Chiu R, Ingham RJ, et al. (1994). "Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes.". J. Immunol. 153 (6): 2369–80. PMID 8077654.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
- Hashimoto S, Gregersen PK, Chiorazzi N (1993). "The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes.". J. Immunol. 150 (2): 491–8. PMID 8419481.
- Wood WJ, Thompson AA, Korenberg J, et al. (1993). "Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB).". Genomics 16 (1): 187–92. doi:. PMID 8486355.
- Thompson AA, Wood WJ, Gilly MJ, et al. (1996). "The promoter and 5' flanking sequences controlling human B29 gene expression.". Blood 87 (2): 666–73. PMID 8555489.
- Astsaturov IA, Matutes E, Morilla R, et al. (1996). "Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia.". Leukemia 10 (5): 769–73. PMID 8656670.
- Koyama M, Nakamura T, Higashihara M, et al. (1996). "The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing.". Immunol. Lett. 47 (3): 151–6. PMID 8747711.
- Carter RH, Doody GM, Bolen JB, Fearon DT (1997). "Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex.". J. Immunol. 158 (7): 3062–9. PMID 9120258.
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