CD49c
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Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
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Identifiers | ||||||||||||||
Symbol(s) | ITGA3; CD49C; FLJ34631; FLJ34704; GAP-B3; GAPB3; MSK18; VCA-2; VL3A; VLA3a | |||||||||||||
External IDs | OMIM: 605025 MGI: 96602 HomoloGene: 21129 | |||||||||||||
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RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 3675 | 16400 | ||||||||||||
Ensembl | ENSG00000005884 | ENSMUSG00000001507 | ||||||||||||
Uniprot | P26006 | Q5SWB9 | ||||||||||||
Refseq | NM_002204 (mRNA) NP_002195 (protein) |
NM_013565 (mRNA) NP_038593 (protein) |
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Location | Chr 17: 45.49 - 45.52 Mb | Chr 11: 94.86 - 94.89 Mb | ||||||||||||
Pubmed search | [1] | [2] |
Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor), also known as ITGA3 and CD49c, is a human gene. ITGA3 is an integrin alpha subunit. It makes up half of the α3β1 integrin duplex.
ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').[1]
[edit] References
[edit] Further reading
- Bosman FT (1993). "Integrins: cell adhesives and modulators of cell function.". Histochem. J. 25 (7): 469–77. PMID 8407358.
- Fornaro M, Languino LR (1998). "Alternatively spliced variants: a new view of the integrin cytoplasmic domain.". Matrix Biol. 16 (4): 185–93. PMID 9402008.