From Wikipedia, the free encyclopedia
Sialophorin (leukosialin, CD43), also known as SPN, is a human gene.[1]
Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.[supplied by OMIM][1]
[edit] References
[edit] Further reading
- Fukuda M, Carlsson SR (1987). "Leukosialin, a major sialoglycoprotein on human leukocytes as differentiation antigens.". Med. Biol. 64 (6): 335–43. PMID 2950285.
- Rogaev EI, Keryanov SA (1993). "Unusual variability of the complex dinucleotide repeat block at the SPN locus.". Hum. Mol. Genet. 1 (8): 657. PMID 1301183.
- Rosenstein Y, Park JK, Hahn WC, et al. (1992). "CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1.". Nature 354 (6350): 233–5. doi:10.1038/354233a0. PMID 1683685.
- Schmid K, Hediger MA, Brossmer R, et al. (1992). "Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin).". Proc. Natl. Acad. Sci. U.S.A. 89 (2): 663–7. PMID 1731338.
- Kudo S, Fukuda M (1991). "A short, novel promoter sequence confers the expression of human leukosialin, a major sialoglycoprotein on leukocytes.". J. Biol. Chem. 266 (13): 8483–9. PMID 1827122.
- Park JK, Rosenstein YJ, Remold-O'Donnell E, et al. (1991). "Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome.". Nature 350 (6320): 706–9. doi:10.1038/350706a0. PMID 2023632.
- Shelley CS, Remold-O'Donnell E, Rosen FS, Whitehead AS (1990). "Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins.". Biochem. J. 270 (3): 569–76. PMID 2241892.
- Pallant A, Eskenazi A, Mattei MG, et al. (1989). "Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16.". Proc. Natl. Acad. Sci. U.S.A. 86 (4): 1328–32. PMID 2521952.
- Shelley CS, Remold-O'Donnell E, Davis AE, et al. (1989). "Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome.". Proc. Natl. Acad. Sci. U.S.A. 86 (8): 2819–23. PMID 2784859.
- Srinivas RV, Su T, Trimble LA, et al. (1996). "Enhanced susceptibility to human immunodeficiency virus infection in CD4+ T lymphocytes genetically deficient in CD43.". AIDS Res. Hum. Retroviruses 11 (9): 1015–21. PMID 8554898.
- Hirao M, Sato N, Kondo T, et al. (1996). "Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.". J. Cell Biol. 135 (1): 37–51. PMID 8858161.
- Yonemura S, Hirao M, Doi Y, et al. (1998). "Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2.". J. Cell Biol. 140 (4): 885–95. PMID 9472040.
- Pedraza-Alva G, Mérida LB, Burakoff SJ, Rosenstein Y (1998). "T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activation.". J. Biol. Chem. 273 (23): 14218–24. PMID 9603925.
- Serrador JM, Nieto M, Alonso-Lebrero JL, et al. (1998). "CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts.". Blood 91 (12): 4632–44. PMID 9616160.
- Pace KE, Lee C, Stewart PL, Baum LG (1999). "Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1.". J. Immunol. 163 (7): 3801–11. PMID 10490978.
- Seveau S, Keller H, Maxfield FR, et al. (2000). "Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule.". Blood 95 (8): 2462–70. PMID 10753822.
- Fratazzi C, Manjunath N, Arbeit RD, et al. (2000). "A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43.". J. Exp. Med. 192 (2): 183–92. PMID 10899905.
- Santana MA, Pedraza-Alva G, Olivares-Zavaleta N, et al. (2000). "CD43-mediated signals induce DNA binding activity of AP-1, NF-AT, and NFkappa B transcription factors in human T lymphocytes.". J. Biol. Chem. 275 (40): 31460–8. doi:10.1074/jbc.M005231200. PMID 10908570.
- van den Berg TK, Nath D, Ziltener HJ, et al. (2001). "Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1).". J. Immunol. 166 (6): 3637–40. PMID 11238599.
[edit] External links
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Proteins: clusters of differentiation (see also list of human clusters of differentiation) |
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| 1-50 |
CD1 ( a-c, 1A, 1D, 1E) - CD2 - CD3 ( γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 ( a) - CD9 - CD10 - CD11 ( a, b, c) - CD13 - CD14 - CD15 - CD16 ( A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 ( A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 ( a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 ( a, b, c, d, e, f) - CD50
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| 51-100 |
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 ( E, L, P) - CD63 - CD64 - CD66 ( a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 ( a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 ( a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
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| 101-150 |
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| 151-200 |
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 ( a, b, c) - CD157 - CD158 ( a, d, e, i, k) - CD159 ( a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 ( a, b) - CD168 - CD169 - CD170 - CD171 - CD172 ( a, b, g) - CD174 - CD177 - CD178 - CD179 ( a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
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| 201-250 |
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| 251-300 |
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| 301-350 |
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