CD300LF

From Wikipedia, the free encyclopedia


CD300 molecule-like family member f
PDB rendering based on 2nms.
Available structures: 2nms
Identifiers
Symbol(s) CD300LF; NKIR; CD300f; CLM1; IREM1; IgSF13
External IDs OMIM: 609807 MGI: 2442359 HomoloGene: 51396
Orthologs
Human Mouse
Entrez 146722 246746
Ensembl ENSG00000186074 ENSMUSG00000047798
Uniprot Q8TDQ1 Q6SJQ7
Refseq NM_139018 (mRNA)
NP_620587 (protein)		 NM_145634 (mRNA)
NP_663609 (protein)
Location Chr 17: 70.2 - 70.22 Mb Chr 11: 114.93 - 114.95 Mb
Pubmed search [1] [2]

CD300 molecule-like family member f, also known as CD300LF, is a human gene.[1]

CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. It mediates negative regulatory signals by recruiting SHP1 (PTPN6; MIM 176883) or SHIP (INPP5D; MIM 601582) (Sui et al., 2004; Alvarez-Errico et al., 2004).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: CD300LF CD300 molecule-like family member f.

[edit] Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Chung DH, Humphrey MB, Nakamura MC, et al. (2004). "CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation.". J. Immunol. 171 (12): 6541–8. PMID 14662855. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Sui L, Li N, Liu Q, et al. (2004). "IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes.". Biochem. Biophys. Res. Commun. 319 (3): 920–8. doi:10.1016/j.bbrc.2004.05.065. PMID 15184070. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Alvarez-Errico D, Aguilar H, Kitzig F, et al. (2005). "IREM-1 is a novel inhibitory receptor expressed by myeloid cells.". Eur. J. Immunol. 34 (12): 3690–701. doi:10.1002/eji.200425433. PMID 15549731. 
  • Alvarez-Errico D, Sayós J, López-Botet M (2007). "The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase.". J. Immunol. 178 (2): 808–16. PMID 17202342. 
 This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.