CD276

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CD276 molecule
Identifiers
Symbol(s) CD276; B7-H3; B7H3
External IDs OMIM: 605715 MGI: 2183926 HomoloGene: 11892
Orthologs
Human Mouse
Entrez 80381 102657
Ensembl ENSG00000103855 ENSMUSG00000035914
Uniprot Q5ZPR3 Q8VE98
Refseq XM_001133846 (mRNA)
XP_001133846 (protein)		 NM_133983 (mRNA)
NP_598744 (protein)
Location Chr 15: 71.76 - 71.79 Mb Chr 9: 58.32 - 58.34 Mb
Pubmed search [1] [2]

CD276 (Cluster of Differentiation 276) is a human protein encoded by the CD276 gene.[1]

Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558).[supplied by OMIM][1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: CD276 CD276 molecule.

[edit] Further reading

  • Chapoval AI, Ni J, Lau JS, et al. (2001). "B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production.". Nat. Immunol. 2 (3): 269-74. doi:10.1038/85339. PMID 11224528. 
  • Sun M, Richards S, Prasad DV, et al. (2002). "Characterization of mouse and human B7-H3 genes.". J. Immunol. 168 (12): 6294-7. PMID 12055244. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ling V, Wu PW, Spaulding V, et al. (2004). "Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss.". Genomics 82 (3): 365-77. PMID 12906861. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Steinberger P, Majdic O, Derdak SV, et al. (2004). "Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains.". J. Immunol. 172 (4): 2352-9. PMID 14764704. 
  • Zhang GB, Chen YJ, Shi Q, et al. (2005). "Human recombinant B7-H3 expressed in E. coli enhances T lymphocyte proliferation and IL-10 secretion in vitro.". Acta Biochim. Biophys. Sin. (Shanghai) 36 (6): 430-6. PMID 15188059. 
  • Castriconi R, Dondero A, Augugliaro R, et al. (2004). "Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis.". Proc. Natl. Acad. Sci. U.S.A. 101 (34): 12640-5. doi:10.1073/pnas.0405025101. PMID 15314238. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wang L, Fraser CC, Kikly K, et al. (2005). "B7-H3 promotes acute and chronic allograft rejection.". Eur. J. Immunol. 35 (2): 428-38. doi:10.1002/eji.200425518. PMID 15682454. 
  • Kim J, Myers AC, Chen L, et al. (2005). "Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells.". Am. J. Respir. Cell Mol. Biol. 33 (3): 280-9. doi:10.1165/rcmb.2004-0129OC. PMID 15961727. 
  • Petroff MG, Kharatyan E, Torry DS, Holets L (2005). "The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placenta.". Am. J. Pathol. 167 (2): 465-73. PMID 16049332. 
  • Zhang GB, Dong QM, Xu Y, et al.. "B7-H3: Another Molecule Marker for Mo-DCs?". Cell. Mol. Immunol. 2 (4): 307-11. PMID 16274630. 
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
  • Sakthivel P, Wang X, Gharizadeh B, et al. (2007). "Single-nucleotide polymorphisms in the B7H3 gene are not associated with human autoimmune myasthenia gravis.". J. Genet. 85 (3): 217-20. PMID 17406098. 

[edit] External links

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v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350