CD207
From Wikipedia, the free encyclopedia
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CD207 molecule, langerin
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| Identifiers | |||||||||||
| Symbol(s) | CD207; CLEC4K; LANGERIN | ||||||||||
| External IDs | OMIM: 604862 MGI: 2180021 HomoloGene: 9252 | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 50489 | 246278 | |||||||||
| Ensembl | ENSG00000116031 | ENSMUSG00000034783 | |||||||||
| Uniprot | Q9UJ71 | Q8VDD4 | |||||||||
| Refseq | NM_015717 (mRNA) NP_056532 (protein) |
NM_144943 (mRNA) NP_659192 (protein) |
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| Location | Chr 2: 70.91 - 70.92 Mb | Chr 6: 83.64 - 83.64 Mb | |||||||||
| Pubmed search | [1] | [2] | |||||||||
CD207, langerin (Cluster of Differentiation 207) is a human protein encoded by the CD207 gene.[1]
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Valladeau J, Dezutter-Dambuyant C, Saeland S (2004). "Langerin/CD207 sheds light on formation of birbeck granules and their possible function in Langerhans cells.". Immunol. Res. 28 (2): 93-107. PMID 14610287.
- Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS.". FASEB J. 20 (13): 2198-208. doi:. PMID 17077296.
- "Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074.
- Valladeau J, Ravel O, Dezutter-Dambuyant C, et al. (2000). "Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules.". Immunity 12 (1): 71-81. PMID 10661407.
- Turville SG, Cameron PU, Handley A, et al. (2002). "Diversity of receptors binding HIV on dendritic cell subsets.". Nat. Immunol. 3 (10): 975-83. doi:. PMID 12352970.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:. PMID 12477932.
- Hunger RE, Sieling PA, Ochoa MT, et al. (2004). "Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.". J. Clin. Invest. 113 (5): 701-8. doi:. PMID 14991068.
- Plzáková Z, Chovanec M, Smetana K, et al. (2005). "Comparison of the expression of Langerin and 175 kD mannose receptor in antigen-presenting cells in normal human skin and basal cell carcinoma.". Folia Biol. (Praha) 50 (2): 71-3. PMID 15222130.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:. PMID 15489334.
- Verdijk P, Dijkman R, Plasmeijer EI, et al. (2005). "A lack of Birbeck granules in Langerhans cells is associated with a naturally occurring point mutation in the human Langerin gene.". J. Invest. Dermatol. 124 (4): 714-7. doi:. PMID 15816828.
- Bousarghin L, Hubert P, Franzen E, et al. (2005). "Human papillomavirus 16 virus-like particles use heparan sulfates to bind dendritic cells and colocalize with langerin in Langerhans cells.". J. Gen. Virol. 86 (Pt 5): 1297-305. doi:. PMID 15831940.
- He B, Qiao X, Klasse PJ, et al. (2006). "HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors.". J. Immunol. 176 (7): 3931-41. PMID 16547227.
- Ward EM, Stambach NS, Drickamer K, Taylor ME (2006). "Polymorphisms in human langerin affect stability and sugar binding activity.". J. Biol. Chem. 281 (22): 15450-6. doi:. PMID 16567809.
- de Witte L, Nabatov A, Pion M, et al. (2007). "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells.". Nat. Med. 13 (3): 367-71. doi:. PMID 17334373.
- Kaplan DH, Li MO, Jenison MC, et al. (2007). "Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells.". J. Exp. Med. 204 (11): 2545-52. doi:. PMID 17938236.
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