CD200R1

From Wikipedia, the free encyclopedia

CD200 receptor 1

Identifiers

CD200R1; HCRTR2; OX2R; CD200R; MOX2R

External IDs

OMIM: 607546 MGI: 1889024 HomoloGene: 10957

Gene ontology
Molecular Function:	• receptor activity • protein binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• cell adhesion

Orthologs

Human

Mouse

Refseq

NM_138806 (mRNA)
NP_620161 (protein)

NM_021325 (mRNA)
NP_067300 (protein)

Location

Chr 3: 114.12 - 114.18 Mb

Chr 16: 44.69 - 44.71 Mb

Pubmed search

[1]

[2]

CD200 receptor 1, also known as CD200R1, is a human gene.^[1]

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.^[1]

[edit] References

^ ^a ^b Entrez Gene: CD200R1 CD200 receptor 1.

[edit] Further reading

Matsue H (2006). "CD 200-mediated regulation of skin immunity.". J. Invest. Dermatol. 125 (6): x-xi. doi:10.1111/j.0022-202X.2005.23978.x. PMID 16354172.
Shiratori I, Yamaguchi M, Suzukawa M, et al. (2005). "Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200.". J. Immunol. 175 (7): 4441-9. PMID 16177086.
Cherwinski HM, Murphy CA, Joyce BL, et al. (2005). "The CD200 receptor is a novel and potent regulator of murine and human mast cell function.". J. Immunol. 174 (3): 1348-56. PMID 15661892.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161.
Foster-Cuevas M, Wright GJ, Puklavec MJ, et al. (2004). "Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.". J. Virol. 78 (14): 7667-76. doi:10.1128/JVI.78.14.7667-7676.2004. PMID 15220441.
Karteris E, Chen J, Randeva HS (2004). "Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system.". J. Clin. Endocrinol. Metab. 89 (4): 1957-62. PMID 15070969.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Wright GJ, Cherwinski H, Foster-Cuevas M, et al. (2003). "Characterization of the CD200 receptor family in mice and humans and their interactions with CD200.". J. Immunol. 171 (6): 3034-46. PMID 12960329.
Vieites JM, de la Torre R, Ortega MA, et al. (2003). "Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13.". Gene 311: 99-104. PMID 12853143.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Dick AD, Broderick C, Forrester JV, Wright GJ (2001). "Distribution of OX2 antigen and OX2 receptor within retina.". Invest. Ophthalmol. Vis. Sci. 42 (1): 170-6. PMID 11133863.
Wright GJ, Puklavec MJ, Willis AC, et al. (2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.". Immunity 13 (2): 233-42. PMID 10981966.