CD1D

From Wikipedia, the free encyclopedia


CD1d molecule
PDB rendering based on 1zt4.
Available structures: 1zt4
Identifiers
Symbol(s) CD1D; CD1A; MGC34622; R3
External IDs OMIM: 188410 MGI: 107674 HomoloGene: 1337
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 912 12479
Ensembl ENSG00000158473 ENSMUSG00000028076
Uniprot P15813 Q91XK9
Refseq NM_001766 (mRNA)
NP_001757 (protein)		 NM_007639 (mRNA)
NP_031665 (protein)
Location Chr 1: 156.42 - 156.42 Mb Chr 3: 87.08 - 87.09 Mb
Pubmed search [1] [2]


CD1d is a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. It is the only member of the group 2 CD1 molecules.

CD1d presented lipid antigens activate a special class of T cells, known as Natural Killer T (NKT) cells. When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and IL-4 production.

[edit] Nomenclature

  • CD1d is also known as R3G1

[edit] Further reading

  • Melián A, Beckman EM, Porcelli SA, Brenner MB (1996). "Antigen presentation by CD1 and MHC-encoded class I-like molecules.". Curr. Opin. Immunol. 8 (1): 82–8. PMID 8729450. 
  • Joyce S (2001). "CD1d and natural T cells: how their properties jump-start the immune system.". Cell. Mol. Life Sci. 58 (3): 442–69. PMID 11315191. 
  • Sköld M, Behar SM (2003). "Role of CD1d-restricted NKT cells in microbial immunity.". Infect. Immun. 71 (10): 5447–55. PMID 14500461. 
  • Brigl M, Brenner MB (2004). "CD1: antigen presentation and T cell function.". Annu. Rev. Immunol. 22: 817–90. doi:10.1146/annurev.immunol.22.012703.104608. PMID 15032598. 
  • Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects.". Curr. HIV Res. 4 (1): 57–64. PMID 16454711. 
  • Brutkiewicz RR (2006). "CD1d ligands: the good, the bad, and the ugly.". J. Immunol. 177 (2): 769–75. PMID 16818729. 
  • Blumberg RS, Terhorst C, Bleicher P, et al. (1991). "Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells.". J. Immunol. 147 (8): 2518–24. PMID 1717564. 
  • Balk SP, Bleicher PA, Terhorst C (1989). "Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule.". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 252–6. PMID 2463622. 
  • Calabi F, Jarvis JM, Martin L, Milstein C (1989). "Two classes of CD1 genes.". Eur. J. Immunol. 19 (2): 285–92. PMID 2467814. 
  • Yu CY, Milstein C (1990). "A physical map linking the five CD1 human thymocyte differentiation antigen genes.". EMBO J. 8 (12): 3727–32. PMID 2583117. 
  • Martin LH, Calabi F, Milstein C (1987). "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9154–8. PMID 3097645. 
  • Balk SP, Burke S, Polischuk JE, et al. (1994). "Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium.". Science 265 (5169): 259–62. PMID 7517575. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Kawano T, Cui J, Koezuka Y, et al. (1997). "CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides.". Science 278 (5343): 1626–9. PMID 9374463. 
  • Katabami S, Matsuura A, Chen HZ, et al. (1998). "Structural organization of rat CD1 typifies evolutionarily conserved CD1D class genes.". Immunogenetics 48 (1): 22–31. PMID 9601940. 
  • Somnay-Wadgaonkar K, Nusrat A, Kim HS, et al. (1999). "Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form.". Int. Immunol. 11 (3): 383–92. PMID 10221650. 
  • Campbell NA, Kim HS, Blumberg RS, Mayer L (1999). "The nonclassical class I molecule CD1d associates with the novel CD8 ligand gp180 on intestinal epithelial cells.". J. Biol. Chem. 274 (37): 26259–65. PMID 10473580. 
  • Han M, Hannick LI, DiBrino M, Robinson MA (2000). "Polymorphism of human CD1 genes.". Tissue Antigens 54 (2): 122–7. PMID 10488738. 

[edit] External links

v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350
Languages