CD160
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CD160 molecule
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| Identifiers | ||||||||||||||
| Symbol(s) | CD160; BY55; FLJ46513; NK1; NK28 | |||||||||||||
| External IDs | OMIM: 604463 MGI: 1860383 HomoloGene: 5122 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 11126 | 54215 | ||||||||||||
| Ensembl | ENSG00000117281 | ENSMUSG00000038304 | ||||||||||||
| Uniprot | O95971 | Q8C9H4 | ||||||||||||
| Refseq | NM_007053 (mRNA) NP_008984 (protein) |
NM_018767 (mRNA) NP_061237 (protein) |
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| Location | Chr 1: 144.41 - 144.43 Mb | Chr 3: 96.89 - 96.9 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
CD160 molecule, also known as CD160, is a human gene.[1]
CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Bensussan A, Gluckman E, el Marsafy S, et al. (1994). "BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic activity.". Proc. Natl. Acad. Sci. U.S.A. 91 (19): 9136-40. PMID 8090781.
- Anumanthan A, Bensussan A, Boumsell L, et al. (1998). "Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes.". J. Immunol. 161 (6): 2780-90. PMID 9743336.
- Agrawal S, Marquet J, Freeman GJ, et al. (1999). "Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells.". J. Immunol. 162 (3): 1223-6. PMID 9973372.
- Nikolova M, Marie-Cardine A, Boumsell L, Bensussan A (2002). "BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression.". Int. Immunol. 14 (5): 445-51. PMID 11978774.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:. PMID 12477932.
- Tanaka J, Toubai T, Tsutsumi Y, et al. (2004). "Cytolytic activity and regulatory functions of inhibitory NK cell receptor-expressing T cells expanded from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells.". Blood 104 (3): 768-74. doi:. PMID 15073036.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:. PMID 15489334.
- Barakonyi A, Rabot M, Marie-Cardine A, et al. (2004). "Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset.". J. Immunol. 173 (9): 5349-54. PMID 15494480.
- Abecassis S, Giustiniani J, Meyer N, et al. (2007). "Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation.". J. Invest. Dermatol. 127 (5): 1161-6. doi:. PMID 17218942.
- Giustiniani J, Marie-Cardine A, Bensussan A (2007). "A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity.". J. Immunol. 178 (3): 1293-300. PMID 17237375.
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