CD15
From Wikipedia, the free encyclopedia
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fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
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| Identifiers | |
| Symbol | FUT4 |
| Alt. Symbols | CD15, FCT3A, ELFT, SSEA-1, LeX |
| Entrez | 2526 |
| HUGO | 4015 |
| OMIM | 104230 |
| RefSeq | NM_002033 |
| UniProt | P22083 |
| Other data | |
| Locus | Chr. 11 q21 |
CD15 (3-fucosyl-N-acetyl-lactosamine) is a cluster of differentiation - an immunologically significant molecule. CD15 is a carbohydrate adhesion molecule (not a protein) that can be expressed on Glycoproteins, Glycolipids and Proteoglycans. It mediates phagocytosis and chemotaxis, found on neutrophils; expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias. It is also called Lewis x and SSEA-1 (stage specific embryonic antigen 1) and represents a marker for murine pluripotent stem cells, in which it plays an important role in adhesion and migration of the cells in the preimplantation embryo. It is synthezised by FUT 4 (fucosyltransferase 4).
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