CD155
From Wikipedia, the free encyclopedia
 |
|
| Poliovirus (in red and blue) bound to CD155 (purple) | |
|
CD155
|
|
| Identifiers | |
| Symbol | CD155 |
| Alt. Symbols | HVED, Necl-5, NECL5, Tage4 |
| Entrez | 5817 |
| OMIM | 173850 |
| RefSeq | NM_006505 |
| UniProt | P15151 |
| Other data | |
| Locus | Chr. 19 q13.2 |
CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily.[1] Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells.[2] The role of CD155 in the immune system is unclear, though it may be involved in intestinal humoral immune responses.[2]
[edit] References
- ^ Mendelsohn CL, Wimmer E, Racaniello VR (1989). "Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily". Cell 56 (5): 855–65. PMID 2538245.
- ^ a b Maier MK, Seth S, Czeloth N, et al (2007). "The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens". doi:. PMID 17621371.
 |
This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it. |
