CCT4

From Wikipedia, the free encyclopedia

Chaperonin containing TCP1, subunit 4 (delta)

Identifiers

CCT4; Cctd; MGC126164; MGC126165; SRB

External IDs

OMIM: 605142 MGI: 104689 HomoloGene: 4695

Gene ontology
Molecular Function:	• nucleotide binding • ATP binding • unfolded protein binding
Cellular Component:	• cytoplasm • chaperonin-containing T-complex
Biological Process:	• regulation of progression through cell cycle • protein folding

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006430 (mRNA)
NP_006421 (protein)

NM_009837 (mRNA)
NP_033967 (protein)

Location

Chr 2: 61.95 - 61.97 Mb

Chr 11: 22.89 - 22.9 Mb

Pubmed search

[1]

[2]

Chaperonin containing TCP1, subunit 4 (delta), also known as CCT4, is a human gene.^[1]

[edit] References

^ Entrez Gene: CCT4 chaperonin containing TCP1, subunit 4 (delta).

[edit] Further reading

Kubota H, Hynes G, Carne A, et al. (1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin.". Curr. Biol. 4 (2): 89–99. PMID 7953530.
Wu-Baer F, Lane WS, Gaynor RB (1996). "Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA.". J. Biol. Chem. 271 (8): 4201–8. PMID 8626763.
Nabetani A, Hatada I, Morisaki H, Mukai T (1997). "Chromosomal assignment and imprinting tests for the mouse delta subunit of the cytosolic chaperonin containing TCP-1 (Cct4) gene to proximal chromosome 11.". Genomics 34 (2): 246–9. doi:10.1006/geno.1996.0276. PMID 8661059.
Melki R, Batelier G, Soulié S, Williams RC (1997). "Cytoplasmic chaperonin containing TCP-1: structural and functional characterization.". Biochemistry 36 (19): 5817–26. doi:10.1021/bi962830o. PMID 9153422.
Won KA, Schumacher RJ, Farr GW, et al. (1998). "Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT.". Mol. Cell. Biol. 18 (12): 7584–9. PMID 9819444.
Llorca O, McCormack EA, Hynes G, et al. (2000). "Eukaryotic type II chaperonin CCT interacts with actin through specific subunits.". Nature 402 (6762): 693–6. doi:10.1038/45294. PMID 10604479.
Llorca O, Martín-Benito J, Gómez-Puertas P, et al. (2002). "Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin.". J. Struct. Biol. 135 (2): 205–18. doi:10.1006/jsbi.2001.4359. PMID 11580270.
Parissi V, Calmels C, De Soultrait VR, et al. (2001). "Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60.". J. Virol. 75 (23): 11344–53. doi:10.1128/JVI.75.23.11344-11353.2001. PMID 11689615.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Imai Y, Soda M, Murakami T, et al. (2004). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.". J. Biol. Chem. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.