CBY1

From Wikipedia, the free encyclopedia

Chibby homolog 1 (Drosophila)

Identifiers

CBY1; C22orf2; CBY; HS508I15A; PGEA1; PIGEA-14; PIGEA14; arb1

External IDs

OMIM: 607757 MGI: 1920989 HomoloGene: 12514

Gene ontology
Molecular Function:	• beta-catenin binding • identical protein binding
Cellular Component:	• nucleus • trans-Golgi network
Biological Process:	• protein localization • negative regulation of Wnt receptor signaling pathway • negative regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001002880 (mRNA)
NP_001002880 (protein)

NM_028634 (mRNA)
NP_082910 (protein)

Location

Chr 22: 37.38 - 37.4 Mb

Chr 15: 79.49 - 79.49 Mb

Pubmed search

[1]

[2]

Chibby homolog 1 (Drosophila), also known as CBY1, is a human gene.^[1]

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: CBY1 chibby homolog 1 (Drosophila).

[edit] Further reading

Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677-84. doi:10.1101/gr.164001. PMID 11337467.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22.". Genome Res. 13 (1): 27-36. doi:10.1101/gr.695703. PMID 12529303.
Takemaru K, Yamaguchi S, Lee YS, et al. (2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway.". Nature 422 (6934): 905-9. doi:10.1038/nature01570. PMID 12712206.
Hidaka S, Könecke V, Osten L, Witzgall R (2004). "PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2.". J. Biol. Chem. 279 (33): 35009-16. doi:10.1074/jbc.M314206200. PMID 15194699.
Gad S, Teboul D, Lièvre A, et al. (2004). "Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ?". BMC Cancer 4: 31. doi:10.1186/1471-2407-4-31. PMID 15245581.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Schuierer MM, Graf E, Takemaru K, et al. (2006). "Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines.". World J. Gastroenterol. 12 (10): 1529-35. PMID 16570344.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Li FQ, Singh AM, Mofunanya A, et al. (2007). "Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling.". Mol. Cell. Biol. 27 (12): 4347-54. doi:10.1128/MCB.01640-06. PMID 17403895.