CBX2 (gene)

From Wikipedia, the free encyclopedia

Chromobox homolog 2 (Pc class homolog, Drosophila)

PDB rendering based on 2d9u.

Available structures: 2d9u

Identifiers

Symbol(s)

CBX2; CDCA6; M33; MGC10561

External IDs

OMIM: 602770 MGI: 88289 HomoloGene: 7256

Gene ontology
Molecular Function:	• DNA binding • chromatin binding • protein binding • transcription repressor activity
Cellular Component:	• chromatin • nucleus • PcG protein complex
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • chromatin assembly or disassembly • transcription • regulation of transcription, DNA-dependent • negative regulation of transcription • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005189 (mRNA)
NP_005180 (protein)

NM_007623 (mRNA)
NP_031649 (protein)

Location

Chr 17: 75.37 - 75.38 Mb

Chr 11: 118.84 - 118.85 Mb

Pubmed search

[1]

[2]

Chromobox homolog 2 (Pc class homolog, Drosophila), also known as CBX2, is a human gene.^[1]

[edit] References

^ Entrez Gene: CBX2 chromobox homolog 2 (Pc class homolog, Drosophila).

[edit] Further reading

Chodak GW (1989). "Early detection and screening for prostatic cancer.". Urology 34 (4 Suppl): 10-2; discussion 46-56. PMID 2477932.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
García E, Marcos-Gutiérrez C, del Mar Lorente M, et al. (1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1.". EMBO J. 18 (12): 3404-18. doi:10.1093/emboj/18.12.3404. PMID 10369680.
Katoh-Fukui Y, Tsuchiya R, Shiroishi T, et al. (1998). "Male-to-female sex reversal in M33 mutant mice.". Nature 393 (6686): 688-92. doi:10.1038/31482. PMID 9641679.
Gecz J, Gaunt SJ, Passage E, et al. (1995). "Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25.". Genomics 26 (1): 130-3. PMID 7782071.
Pearce JJ, Singh PB, Gaunt SJ (1992). "The mouse has a Polycomb-like chromobox gene.". Development 114 (4): 921-9. PMID 1352241.