CAV1

From Wikipedia, the free encyclopedia

Caveolin 1, caveolae protein, 22kDa

Identifiers

CAV1; CAV; MSTP085; VIP21

External IDs

OMIM: 601047 MGI: 102709 HomoloGene: 1330

Gene ontology
Molecular Function:	• structural molecule activity • protein binding • cholesterol binding
Cellular Component:	• Golgi membrane • integral to membrane of membrane fraction • endoplasmic reticulum • plasma membrane • integral to plasma membrane • caveolar membrane • lipid raft • perinuclear region of cytoplasm
Biological Process:	• inactivation of MAPK activity • negative regulation of endothelial cell proliferation • triacylglycerol metabolic process • negative regulation of signal transduction • regulation of fatty acid metabolic process • sequestering of lipid • cholesterol transport • cholesterol homeostasis • negative regulation of nitric oxide biosynthetic process • positive regulation of vasoconstriction • negative regulation of vasodilation • protein homooligomerization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001753 (mRNA)
NP_001744 (protein)

NM_007616 (mRNA)
NP_031642 (protein)

Location

Chr 7: 115.95 - 115.99 Mb

Chr 6: 17.26 - 17.29 Mb

Pubmed search

[1]

[2]

Caveolin 1, caveolae protein, 22kDa, also known as CAV1, is a human gene.

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.^[1]

[edit] See also

Caveolin

[edit] References

^ Entrez Gene: CAV1 caveolin 1, caveolae protein, 22kDa.

[edit] Further reading

Engelman JA, Zhang X, Galbiati F, et al. (1999). "Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy.". Am. J. Hum. Genet. 63 (6): 1578–87. PMID 9837809.
Razani B, Schlegel A, Liu J, Lisanti MP (2002). "Caveolin-1, a putative tumour suppressor gene.". Biochem. Soc. Trans. 29 (Pt 4): 494–9. PMID 11498016.
Fujimoto T, Kogo H, Nakamura N, Ozeki S (2002). "[Microdomains and caveolin]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 326–32. PMID 11915322.
Shatz M, Liscovitch M (2004). "Caveolin-1 and cancer multidrug resistance: coordinate regulation of pro-survival proteins?". Leuk. Res. 28 (9): 907–8. doi:10.1016/j.leukres.2004.03.013. PMID 15234566.
Frank PG, Lisanti MP (2007). "Caveolin-1 and liver regeneration: role in proliferation and lipogenesis.". Cell Cycle 6 (2): 115–6. PMID 17314510.