Cation channels of sperm

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cation channel, sperm associated 1
Identifiers
Symbol CATSPER1
Entrez 117144
HUGO 17116
OMIM 606389
RefSeq NM_053054
UniProt Q8NEC5
Other data
Locus Chr. 11 q12.1
cation channel, sperm associated 2
Identifiers
Symbol CATSPER2
Entrez 117155
HUGO 18810
OMIM 607249
RefSeq NM_172097
UniProt Q96P55
Other data
Locus Chr. 15 q13-q15
cation channel, sperm associated 3
Identifiers
Symbol CATSPER3
Entrez 347732
HUGO 20819
OMIM 609120
RefSeq NM_178019
UniProt Q86XQ3
Other data
Locus Chr. 5 q31.2
cation channel, sperm associated 4
Identifiers
Symbol CATSPER4
Entrez 378807
HUGO 23220
OMIM 609121
RefSeq XM_371237
UniProt Q7RTX7
Other data
Locus Chr. 1 p35.3

Cation channels of sperm: This small family of ion channels, normally referred to as Catsper channels or CatSper, is related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca2+ channels that seem to be specific to sperm. These channels are required for proper fertilization. The study of these channels has been slow because they do not traffic to the cell membrane in many heterologous systems.

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v • d • e
Membrane transport protein: ion channels
Ca2+: Calcium channel
Voltage-dependent calcium channel (L-type/Cavα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Cavα(2.1), Q-type, R-type, T-type, α2δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4)
Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Navβ (1, 2, 3, 4) • Epithelial sodium channel
K+: Potassium channel
Cl-: Chloride channel
Porin
Cations: TRP
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
Other/general