Cathepsin B
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Cathepsin B
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| Available structures: 1csb, 1gmy, 1huc, 1pbh, 1sp4, 2ipp, 2pbh, 3pbh | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | CTSB; APPS; CPSB | |||||||||||||
| External IDs | OMIM: 116810 MGI: 88561 HomoloGene: 37550 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 1508 | 13030 | ||||||||||||
| Ensembl | ENSG00000164733 | ENSMUSG00000021939 | ||||||||||||
| Uniprot | P07858 | Q3TC17 | ||||||||||||
| Refseq | NM_001908 (mRNA) NP_001899 (protein) |
NM_007798 (mRNA) NP_031824 (protein) |
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| Location | Chr 8: 11.74 - 11.76 Mb | Chr 14: 62.08 - 62.1 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Cathepsin B, also known as CTSB, is a human gene.
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[edit] Function
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It was once suspected as a candidate protease responsible for the generation of beta-amyloid from the amyloid precursor protein (APP) secretase, but this function is now known to be due to the action of the presenilin/g-secretase complex. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.[1]
Cathepsin B seems to actually break down the proteins which cause amyloid plaque, the root of Alzheimer's symptoms, and may even be a pivotal part of the natural defense against this disease used by people who do not get it.[2][3]
[edit] See also
[edit] References
- ^ Entrez Gene: CTSB cathepsin B.
- ^ Mueller-Steiner S, Zhou Y, Arai H, Roberson E, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L (2006). "Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease". Neuron 51 (6): 703–14. doi:. PMID 16982417.
- ^ Enzyme shreds Alzheimer's protein (2006-09-21). Retrieved on 2007-11-07.
[edit] Further reading
- Yan S, Sloane BF (2004). "Molecular regulation of human cathepsin B: implication in pathologies.". Biol. Chem. 384 (6): 845–54. PMID 12887051.
[edit] External links
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