Caspase 7

From Wikipedia, the free encyclopedia

Caspase 7, apoptosis-related cysteine peptidase

PDB rendering based on 1f1j.

Available structures: 1f1j, 1gqf, 1i4o, 1i51, 1k86, 1k88, 1kmc, 1shj, 1shl

Identifiers

Symbol(s)

CASP7; CMH-1; ICE-LAP3; MCH3

External IDs

OMIM: 601761 MGI: 109383 HomoloGene: 11168

Gene ontology
Molecular Function:	• protein binding • peptidase activity • cysteine-type peptidase activity • caspase activity
Cellular Component:	• cytoplasm • endoplasmic reticulum membrane • mitochondrial membrane
Biological Process:	• release of cytochrome c from mitochondria • proteolysis • heart development • apoptotic program • response to UV

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001227 (mRNA)
NP_001218 (protein)

NM_007611 (mRNA)
NP_031637 (protein)

Location

Chr 10: 115.43 - 115.48 Mb

Chr 19: 56.46 - 56.49 Mb

Pubmed search

[1]

[2]

Caspase 7, apoptosis-related cysteine peptidase, also known as CASP7, is a human protein and gene.

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and caspase 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms.^[1]