Caspase 4

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caspase 4, apoptosis-related cysteine peptidase
Identifiers
Symbol	CASP4
Alt. Symbols	ICE(rel)II, ICH-2, TX
Entrez	837
HUGO	1505
OMIM	602664
RefSeq	NM_001225
UniProt	P49662
Other data
EC number	3.4.22.57
Locus	Chr. 11 q22.2-q22.3

Caspase 4 is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue, and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and the murine homolog caspase 11), with a role in the immune system.^[1]

[edit] References

1. ^ Martinon F, Tschopp J (2007). "Inflammatory caspases and inflammasomes: master switches of inflammation". Cell Death Differ. 14 (1): 10–22. doi:10.1038/sj.cdd.4402038. PMID 16977329. 

v • d • e Proteases: cysteine proteases (EC 3.4.22) Caspase Caspase 1 - Caspase 2 - Caspase 3 - Caspase 4 - Caspase 5 - Caspase 8 - Caspase 9 - Caspase 10 - Caspase 12 - Caspase 13 Fruit-derived Papain - Ficain - Bromelain - Actinidain Other Clostripain - Cancer procoagulant - Separase - Calpain - Autophagin